Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling

Therapeutic targeting of tumor angiogenesis with VEGF inhibitors results in demonstrable, but transitory efficacy in certain human tumors and mouse models of cancer, limited by unconventional forms of adaptive/evasive resistance. In one such mouse model, potent angiogenesis inhibitors elicit compart...

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Detalles Bibliográficos
Autores principales: Allen, Elizabeth, Miéville, Pascal, Warren, Carmen M., Saghafinia, Sadegh, Li, Leanne, Peng, Mei-Wen, Hanahan, Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872464/
https://www.ncbi.nlm.nih.gov/pubmed/27134166
http://dx.doi.org/10.1016/j.celrep.2016.04.029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872464/
https://www.ncbi.nlm.nih.gov/pubmed/27134166
http://dx.doi.org/10.1016/j.celrep.2016.04.029

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