High prevalence of side population in human cancer cell lines

Cancer cell lines are essential platforms for performing cancer research on human cells. We here demonstrate that, across tumor entities, human cancer cell lines harbor minority populations of putative stem-like cells, molecularly defined by dye extrusion resulting in the side population phenotype....

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Detalles Bibliográficos
Autores principales: Boesch, Maximilian, Zeimet, Alain G., Fiegl, Heidi, Wolf, Barbara, Huber, Julia, Klocker, Helmut, Gastl, Guenther, Sopper, Sieghart, Wolf, Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872646/
https://www.ncbi.nlm.nih.gov/pubmed/27226981
http://dx.doi.org/10.18632/oncoscience.300
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author Boesch, Maximilian
Zeimet, Alain G.
Fiegl, Heidi
Wolf, Barbara
Huber, Julia
Klocker, Helmut
Gastl, Guenther
Sopper, Sieghart
Wolf, Dominik
author_facet Boesch, Maximilian
Zeimet, Alain G.
Fiegl, Heidi
Wolf, Barbara
Huber, Julia
Klocker, Helmut
Gastl, Guenther
Sopper, Sieghart
Wolf, Dominik
author_sort Boesch, Maximilian
collection PubMed
description Cancer cell lines are essential platforms for performing cancer research on human cells. We here demonstrate that, across tumor entities, human cancer cell lines harbor minority populations of putative stem-like cells, molecularly defined by dye extrusion resulting in the side population phenotype. These findings establish a heterogeneous nature of human cancer cell lines and argue for their stem cell origin. This should be considered when interpreting research involving these model systems.
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spelling pubmed-48726462016-05-25 High prevalence of side population in human cancer cell lines Boesch, Maximilian Zeimet, Alain G. Fiegl, Heidi Wolf, Barbara Huber, Julia Klocker, Helmut Gastl, Guenther Sopper, Sieghart Wolf, Dominik Oncoscience Brief Report Cancer cell lines are essential platforms for performing cancer research on human cells. We here demonstrate that, across tumor entities, human cancer cell lines harbor minority populations of putative stem-like cells, molecularly defined by dye extrusion resulting in the side population phenotype. These findings establish a heterogeneous nature of human cancer cell lines and argue for their stem cell origin. This should be considered when interpreting research involving these model systems. Impact Journals LLC 2016-04-10 /pmc/articles/PMC4872646/ /pubmed/27226981 http://dx.doi.org/10.18632/oncoscience.300 Text en Copyright: © 2016 Boesch et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Brief Report
Boesch, Maximilian
Zeimet, Alain G.
Fiegl, Heidi
Wolf, Barbara
Huber, Julia
Klocker, Helmut
Gastl, Guenther
Sopper, Sieghart
Wolf, Dominik
High prevalence of side population in human cancer cell lines
title High prevalence of side population in human cancer cell lines
title_full High prevalence of side population in human cancer cell lines
title_fullStr High prevalence of side population in human cancer cell lines
title_full_unstemmed High prevalence of side population in human cancer cell lines
title_short High prevalence of side population in human cancer cell lines
title_sort high prevalence of side population in human cancer cell lines
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872646/
https://www.ncbi.nlm.nih.gov/pubmed/27226981
http://dx.doi.org/10.18632/oncoscience.300
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