Extracorporeal Shock Wave Treatment (ESWT) enhances the in vitro-induced differentiation of human tendon-derived stem/progenitor cells (hTSPCs)

Extracorporeal shock wave therapy (ESWT) is a non-invasive and innovative technology for the management of specific tendinopathies. In order to elucidate the ESWT-mediated clinical benefits, human Tendon-derived Stem/Progenitor cells (hTSPCs) explanted from 5 healthy semitendinosus (ST) and 5 ruptur...

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Autores principales: Leone, Laura, Raffa, Salvatore, Vetrano, Mario, Ranieri, Danilo, Malisan, Florence, Scrofani, Cristina, Vulpiani, Maria Chiara, Ferretti, Andrea, Torrisi, Maria Rosaria, Visco, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872723/
https://www.ncbi.nlm.nih.gov/pubmed/26843618
http://dx.doi.org/10.18632/oncotarget.7064
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author Leone, Laura
Raffa, Salvatore
Vetrano, Mario
Ranieri, Danilo
Malisan, Florence
Scrofani, Cristina
Vulpiani, Maria Chiara
Ferretti, Andrea
Torrisi, Maria Rosaria
Visco, Vincenzo
author_facet Leone, Laura
Raffa, Salvatore
Vetrano, Mario
Ranieri, Danilo
Malisan, Florence
Scrofani, Cristina
Vulpiani, Maria Chiara
Ferretti, Andrea
Torrisi, Maria Rosaria
Visco, Vincenzo
author_sort Leone, Laura
collection PubMed
description Extracorporeal shock wave therapy (ESWT) is a non-invasive and innovative technology for the management of specific tendinopathies. In order to elucidate the ESWT-mediated clinical benefits, human Tendon-derived Stem/Progenitor cells (hTSPCs) explanted from 5 healthy semitendinosus (ST) and 5 ruptured Achilles (AT) tendons were established. While hTSPCs from the two groups showed similar proliferation rates and stem cell surface marker profiles, we found that the clonogenic potential was maintained only in cells derived from healthy donors. Interestingly, ESWT significantly accelerated hTSPCs differentiation, suggesting that the clinical benefits of ESWT may be ascribed to increased efficiency of tendon repair after injury.
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spelling pubmed-48727232016-05-25 Extracorporeal Shock Wave Treatment (ESWT) enhances the in vitro-induced differentiation of human tendon-derived stem/progenitor cells (hTSPCs) Leone, Laura Raffa, Salvatore Vetrano, Mario Ranieri, Danilo Malisan, Florence Scrofani, Cristina Vulpiani, Maria Chiara Ferretti, Andrea Torrisi, Maria Rosaria Visco, Vincenzo Oncotarget Research Paper: Pathology Extracorporeal shock wave therapy (ESWT) is a non-invasive and innovative technology for the management of specific tendinopathies. In order to elucidate the ESWT-mediated clinical benefits, human Tendon-derived Stem/Progenitor cells (hTSPCs) explanted from 5 healthy semitendinosus (ST) and 5 ruptured Achilles (AT) tendons were established. While hTSPCs from the two groups showed similar proliferation rates and stem cell surface marker profiles, we found that the clonogenic potential was maintained only in cells derived from healthy donors. Interestingly, ESWT significantly accelerated hTSPCs differentiation, suggesting that the clinical benefits of ESWT may be ascribed to increased efficiency of tendon repair after injury. Impact Journals LLC 2016-01-28 /pmc/articles/PMC4872723/ /pubmed/26843618 http://dx.doi.org/10.18632/oncotarget.7064 Text en Copyright: © 2016 Leone et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper: Pathology
Leone, Laura
Raffa, Salvatore
Vetrano, Mario
Ranieri, Danilo
Malisan, Florence
Scrofani, Cristina
Vulpiani, Maria Chiara
Ferretti, Andrea
Torrisi, Maria Rosaria
Visco, Vincenzo
Extracorporeal Shock Wave Treatment (ESWT) enhances the in vitro-induced differentiation of human tendon-derived stem/progenitor cells (hTSPCs)
title Extracorporeal Shock Wave Treatment (ESWT) enhances the in vitro-induced differentiation of human tendon-derived stem/progenitor cells (hTSPCs)
title_full Extracorporeal Shock Wave Treatment (ESWT) enhances the in vitro-induced differentiation of human tendon-derived stem/progenitor cells (hTSPCs)
title_fullStr Extracorporeal Shock Wave Treatment (ESWT) enhances the in vitro-induced differentiation of human tendon-derived stem/progenitor cells (hTSPCs)
title_full_unstemmed Extracorporeal Shock Wave Treatment (ESWT) enhances the in vitro-induced differentiation of human tendon-derived stem/progenitor cells (hTSPCs)
title_short Extracorporeal Shock Wave Treatment (ESWT) enhances the in vitro-induced differentiation of human tendon-derived stem/progenitor cells (hTSPCs)
title_sort extracorporeal shock wave treatment (eswt) enhances the in vitro-induced differentiation of human tendon-derived stem/progenitor cells (htspcs)
topic Research Paper: Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872723/
https://www.ncbi.nlm.nih.gov/pubmed/26843618
http://dx.doi.org/10.18632/oncotarget.7064
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