Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target

Multiple myeloma (MM) is a malignancy of the antibody-producing plasma cells. MM is a highly heterogeneous disease, which has hampered the identification of a common underlying mechanism for disease establishment as well as the development of targeted therapy. Here we present the first genome-wide p...

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Detalles Bibliográficos
Autores principales: Agarwal, Prasoon, Alzrigat, Mohammad, Párraga, Alba Atienza, Enroth, Stefan, Singh, Umashankar, Ungerstedt, Johanna, Österborg, Anders, Brown, Peter J., Ma, Anqi, Jin, Jian, Nilsson, Kenneth, Öberg, Fredrik, Kalushkova, Antonia, Jernberg-Wiklund, Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872750/
https://www.ncbi.nlm.nih.gov/pubmed/26755663
http://dx.doi.org/10.18632/oncotarget.6843

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