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Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes

AIMS: 3′,5′-Cyclic adenosine monophosphate (cAMP) signals in the heart are often confined to concentration microdomains shaped by cAMP diffusion and enzymatic degradation. While the importance of phosphodiesterases (degradative enzymes) in sculpting cAMP microdomains is well established in cardiomyo...

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Detalles Bibliográficos
Autores principales:	Richards, Mark, Lomas, Oliver, Jalink, Kees, Ford, Kerrie L., Vaughan-Jones, Richard D., Lefkimmiatis, Konstantinos, Swietach, Pawel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872880/ https://www.ncbi.nlm.nih.gov/pubmed/27089919 http://dx.doi.org/10.1093/cvr/cvw080

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