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Infections and systemic lupus erythematosus

OBJECTIVE: To determine the incidence of infections in a population of systemic lupus erythematosus individuals and the characteristics of infections regarding original site, as well as to study the possible associations between infections and treatment. METHODS: An analytical retrospective study us...

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Autores principales: Skare, Thelma Larocca, Dagostini, Jéssica Scherer, Zanardi, Patricia Imai, Nisihara, Renato Mitsunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Israelita de Ensino e Pesquisa Albert Einstein 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872917/
https://www.ncbi.nlm.nih.gov/pubmed/27074234
http://dx.doi.org/10.1590/S1679-45082016AO3490
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author Skare, Thelma Larocca
Dagostini, Jéssica Scherer
Zanardi, Patricia Imai
Nisihara, Renato Mitsunori
author_facet Skare, Thelma Larocca
Dagostini, Jéssica Scherer
Zanardi, Patricia Imai
Nisihara, Renato Mitsunori
author_sort Skare, Thelma Larocca
collection PubMed
description OBJECTIVE: To determine the incidence of infections in a population of systemic lupus erythematosus individuals and the characteristics of infections regarding original site, as well as to study the possible associations between infections and treatment. METHODS: An analytical retrospective study using data from medical charts of systemic lupus erythematosus patients from a single university hospital. A total of 144 patients followed up for five years were included. Data collected comprised age of patients and age at onset of lupus, sex and ethnicity, disease duration before the study period, medications, cumulative dose of prednisone, occurrence of infections and their original site. RESULTS: The most frequent infections were urinary tract infections (correlated to use of prednisone − p<0.0001 and cyclophosphamide − p=0.045), upper airways infections (correlated to use of prednisone − p=0.0004, mycophenolate mofetil − p=0.0005, and cyclosporine − p=0.025), and pneumonia (associated to prednisone − p=0.017). CONCLUSION: Prednisone was the drug more often associated with presence of infections, pointing to the need for a more judicious management of this drug.
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spelling pubmed-48729172016-08-10 Infections and systemic lupus erythematosus Skare, Thelma Larocca Dagostini, Jéssica Scherer Zanardi, Patricia Imai Nisihara, Renato Mitsunori Einstein (Sao Paulo) Original Article OBJECTIVE: To determine the incidence of infections in a population of systemic lupus erythematosus individuals and the characteristics of infections regarding original site, as well as to study the possible associations between infections and treatment. METHODS: An analytical retrospective study using data from medical charts of systemic lupus erythematosus patients from a single university hospital. A total of 144 patients followed up for five years were included. Data collected comprised age of patients and age at onset of lupus, sex and ethnicity, disease duration before the study period, medications, cumulative dose of prednisone, occurrence of infections and their original site. RESULTS: The most frequent infections were urinary tract infections (correlated to use of prednisone − p<0.0001 and cyclophosphamide − p=0.045), upper airways infections (correlated to use of prednisone − p=0.0004, mycophenolate mofetil − p=0.0005, and cyclosporine − p=0.025), and pneumonia (associated to prednisone − p=0.017). CONCLUSION: Prednisone was the drug more often associated with presence of infections, pointing to the need for a more judicious management of this drug. Instituto Israelita de Ensino e Pesquisa Albert Einstein 2016 /pmc/articles/PMC4872917/ /pubmed/27074234 http://dx.doi.org/10.1590/S1679-45082016AO3490 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Skare, Thelma Larocca
Dagostini, Jéssica Scherer
Zanardi, Patricia Imai
Nisihara, Renato Mitsunori
Infections and systemic lupus erythematosus
title Infections and systemic lupus erythematosus
title_full Infections and systemic lupus erythematosus
title_fullStr Infections and systemic lupus erythematosus
title_full_unstemmed Infections and systemic lupus erythematosus
title_short Infections and systemic lupus erythematosus
title_sort infections and systemic lupus erythematosus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872917/
https://www.ncbi.nlm.nih.gov/pubmed/27074234
http://dx.doi.org/10.1590/S1679-45082016AO3490
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