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Infections and systemic lupus erythematosus
OBJECTIVE: To determine the incidence of infections in a population of systemic lupus erythematosus individuals and the characteristics of infections regarding original site, as well as to study the possible associations between infections and treatment. METHODS: An analytical retrospective study us...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto Israelita de Ensino e Pesquisa Albert Einstein
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872917/ https://www.ncbi.nlm.nih.gov/pubmed/27074234 http://dx.doi.org/10.1590/S1679-45082016AO3490 |
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author | Skare, Thelma Larocca Dagostini, Jéssica Scherer Zanardi, Patricia Imai Nisihara, Renato Mitsunori |
author_facet | Skare, Thelma Larocca Dagostini, Jéssica Scherer Zanardi, Patricia Imai Nisihara, Renato Mitsunori |
author_sort | Skare, Thelma Larocca |
collection | PubMed |
description | OBJECTIVE: To determine the incidence of infections in a population of systemic lupus erythematosus individuals and the characteristics of infections regarding original site, as well as to study the possible associations between infections and treatment. METHODS: An analytical retrospective study using data from medical charts of systemic lupus erythematosus patients from a single university hospital. A total of 144 patients followed up for five years were included. Data collected comprised age of patients and age at onset of lupus, sex and ethnicity, disease duration before the study period, medications, cumulative dose of prednisone, occurrence of infections and their original site. RESULTS: The most frequent infections were urinary tract infections (correlated to use of prednisone − p<0.0001 and cyclophosphamide − p=0.045), upper airways infections (correlated to use of prednisone − p=0.0004, mycophenolate mofetil − p=0.0005, and cyclosporine − p=0.025), and pneumonia (associated to prednisone − p=0.017). CONCLUSION: Prednisone was the drug more often associated with presence of infections, pointing to the need for a more judicious management of this drug. |
format | Online Article Text |
id | pubmed-4872917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
record_format | MEDLINE/PubMed |
spelling | pubmed-48729172016-08-10 Infections and systemic lupus erythematosus Skare, Thelma Larocca Dagostini, Jéssica Scherer Zanardi, Patricia Imai Nisihara, Renato Mitsunori Einstein (Sao Paulo) Original Article OBJECTIVE: To determine the incidence of infections in a population of systemic lupus erythematosus individuals and the characteristics of infections regarding original site, as well as to study the possible associations between infections and treatment. METHODS: An analytical retrospective study using data from medical charts of systemic lupus erythematosus patients from a single university hospital. A total of 144 patients followed up for five years were included. Data collected comprised age of patients and age at onset of lupus, sex and ethnicity, disease duration before the study period, medications, cumulative dose of prednisone, occurrence of infections and their original site. RESULTS: The most frequent infections were urinary tract infections (correlated to use of prednisone − p<0.0001 and cyclophosphamide − p=0.045), upper airways infections (correlated to use of prednisone − p=0.0004, mycophenolate mofetil − p=0.0005, and cyclosporine − p=0.025), and pneumonia (associated to prednisone − p=0.017). CONCLUSION: Prednisone was the drug more often associated with presence of infections, pointing to the need for a more judicious management of this drug. Instituto Israelita de Ensino e Pesquisa Albert Einstein 2016 /pmc/articles/PMC4872917/ /pubmed/27074234 http://dx.doi.org/10.1590/S1679-45082016AO3490 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Skare, Thelma Larocca Dagostini, Jéssica Scherer Zanardi, Patricia Imai Nisihara, Renato Mitsunori Infections and systemic lupus erythematosus |
title | Infections and systemic lupus erythematosus |
title_full | Infections and systemic lupus erythematosus |
title_fullStr | Infections and systemic lupus erythematosus |
title_full_unstemmed | Infections and systemic lupus erythematosus |
title_short | Infections and systemic lupus erythematosus |
title_sort | infections and systemic lupus erythematosus |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872917/ https://www.ncbi.nlm.nih.gov/pubmed/27074234 http://dx.doi.org/10.1590/S1679-45082016AO3490 |
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