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Hypericum perforatum-induced hepatotoxicity with possible association with copaiba (Copaifera langsdorffii Desf):case report

We report a case of liver damage in an elderly patient after the use of herbal products of Hypericum perforatum and copaiba (Copaifera langsdorffii Desf). Hepatotoxicity related to Hypericum perforatum is anecdotally known, but for copaiba, widely used as anti-inflammatory, there is just experimenta...

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Autores principales: Agollo, Marjorie Costa, Miszputen, Sender Jankiel, Diament, Jayme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Israelita de Ensino e Pesquisa Albert Einstein 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872950/
https://www.ncbi.nlm.nih.gov/pubmed/25167337
http://dx.doi.org/10.1590/S1679-45082014RC2953
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author Agollo, Marjorie Costa
Miszputen, Sender Jankiel
Diament, Jayme
author_facet Agollo, Marjorie Costa
Miszputen, Sender Jankiel
Diament, Jayme
author_sort Agollo, Marjorie Costa
collection PubMed
description We report a case of liver damage in an elderly patient after the use of herbal products of Hypericum perforatum and copaiba (Copaifera langsdorffii Desf). Hepatotoxicity related to Hypericum perforatum is anecdotally known, but for copaiba, widely used as anti-inflammatory, there is just experimental data in the national literature. This report aimed to draw attention to the possible toxic effects of this association as well as to the clinical recovery of the patient after discontinuing their use. There is a tendency to suspect of the action of drugs to justify a non-viral acute liver injury, because of the large number of drugs responsible for hepatotoxicity. There are experiments and clinical reports in the literature describing some herbal products, including Hypericum perforatum, as the causative agents of this aggression, and are considered innocuous and used with no restrictions. We must remember that adverse reactions also occur with these substances; hence, they should be investigated when collecting the patient´s history, for leading to severe liver failure.
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spelling pubmed-48729502016-08-10 Hypericum perforatum-induced hepatotoxicity with possible association with copaiba (Copaifera langsdorffii Desf):case report Agollo, Marjorie Costa Miszputen, Sender Jankiel Diament, Jayme Einstein (Sao Paulo) Case Report We report a case of liver damage in an elderly patient after the use of herbal products of Hypericum perforatum and copaiba (Copaifera langsdorffii Desf). Hepatotoxicity related to Hypericum perforatum is anecdotally known, but for copaiba, widely used as anti-inflammatory, there is just experimental data in the national literature. This report aimed to draw attention to the possible toxic effects of this association as well as to the clinical recovery of the patient after discontinuing their use. There is a tendency to suspect of the action of drugs to justify a non-viral acute liver injury, because of the large number of drugs responsible for hepatotoxicity. There are experiments and clinical reports in the literature describing some herbal products, including Hypericum perforatum, as the causative agents of this aggression, and are considered innocuous and used with no restrictions. We must remember that adverse reactions also occur with these substances; hence, they should be investigated when collecting the patient´s history, for leading to severe liver failure. Instituto Israelita de Ensino e Pesquisa Albert Einstein 2014 /pmc/articles/PMC4872950/ /pubmed/25167337 http://dx.doi.org/10.1590/S1679-45082014RC2953 Text en http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License.
spellingShingle Case Report
Agollo, Marjorie Costa
Miszputen, Sender Jankiel
Diament, Jayme
Hypericum perforatum-induced hepatotoxicity with possible association with copaiba (Copaifera langsdorffii Desf):case report
title Hypericum perforatum-induced hepatotoxicity with possible association with copaiba (Copaifera langsdorffii Desf):case report
title_full Hypericum perforatum-induced hepatotoxicity with possible association with copaiba (Copaifera langsdorffii Desf):case report
title_fullStr Hypericum perforatum-induced hepatotoxicity with possible association with copaiba (Copaifera langsdorffii Desf):case report
title_full_unstemmed Hypericum perforatum-induced hepatotoxicity with possible association with copaiba (Copaifera langsdorffii Desf):case report
title_short Hypericum perforatum-induced hepatotoxicity with possible association with copaiba (Copaifera langsdorffii Desf):case report
title_sort hypericum perforatum-induced hepatotoxicity with possible association with copaiba (copaifera langsdorffii desf):case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872950/
https://www.ncbi.nlm.nih.gov/pubmed/25167337
http://dx.doi.org/10.1590/S1679-45082014RC2953
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