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Invasive candidiasis and oral manifestations in premature newborns
OBJECTIVE: To investigate prevalence of invasive candidiasis in a Neonatal Intensive Care Unit and to evaluate oral diseases and Candida spp. colonization in low birth weight preterm newborns. METHODS: A descriptive epidemiological study performed in two stages. First, prevalence of candidiasis was...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto Israelita de Ensino e Pesquisa Albert Einstein
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872971/ https://www.ncbi.nlm.nih.gov/pubmed/23579747 http://dx.doi.org/10.1590/S1679-45082013000100013 |
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author | Tinoco-Araujo, José Endrigo Araújo, Diana Ferreira Gadelha Barbosa, Patrícia Gomes Santos, Paulo Sérgio da Silva de Medeiros, Ana Myriam Costa |
author_facet | Tinoco-Araujo, José Endrigo Araújo, Diana Ferreira Gadelha Barbosa, Patrícia Gomes Santos, Paulo Sérgio da Silva de Medeiros, Ana Myriam Costa |
author_sort | Tinoco-Araujo, José Endrigo |
collection | PubMed |
description | OBJECTIVE: To investigate prevalence of invasive candidiasis in a Neonatal Intensive Care Unit and to evaluate oral diseases and Candida spp. colonization in low birth weight preterm newborns. METHODS: A descriptive epidemiological study performed in two stages. First, prevalence of candidiasis was analyzed in a database of 295 preterm patients admitted to hospital for over 10 days and birth weight less than 2,000g. In the second stage, oral changes and Candida spp. colonization were assessed in 65 patients weighing less than 2,000g, up to 4 week-old, hospitalized for over 10 days and presenting oral abnormalities compatible with fungal lesions. Swab samples were collected in the mouth to identify fungi. RESULTS: Prevalence of candidiasis was 5.4% in the database analyzed. It correlated with prolonged hospital length of stay (p<0.001), in average, 31 days, and 85% risk of developing infection in the first 25 days. It correlated with low birth weight (p<0.001), with mean of 1,140g. The most frequent alterations were white soft plaques, detachable, in oral mucosa and tongue. Intense oral colonization by Candida spp was observed (80%). CONCLUSIONS: The frequency of invasive candidiasis was low and correlated with low birth weight and prolonged hospital stay. The most common oral changes were white plaques compatible with pseudomembranous candidiasis and colonization by Candida spp. was above average. |
format | Online Article Text |
id | pubmed-4872971 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
record_format | MEDLINE/PubMed |
spelling | pubmed-48729712016-08-10 Invasive candidiasis and oral manifestations in premature newborns Tinoco-Araujo, José Endrigo Araújo, Diana Ferreira Gadelha Barbosa, Patrícia Gomes Santos, Paulo Sérgio da Silva de Medeiros, Ana Myriam Costa Einstein (Sao Paulo) Original Article OBJECTIVE: To investigate prevalence of invasive candidiasis in a Neonatal Intensive Care Unit and to evaluate oral diseases and Candida spp. colonization in low birth weight preterm newborns. METHODS: A descriptive epidemiological study performed in two stages. First, prevalence of candidiasis was analyzed in a database of 295 preterm patients admitted to hospital for over 10 days and birth weight less than 2,000g. In the second stage, oral changes and Candida spp. colonization were assessed in 65 patients weighing less than 2,000g, up to 4 week-old, hospitalized for over 10 days and presenting oral abnormalities compatible with fungal lesions. Swab samples were collected in the mouth to identify fungi. RESULTS: Prevalence of candidiasis was 5.4% in the database analyzed. It correlated with prolonged hospital length of stay (p<0.001), in average, 31 days, and 85% risk of developing infection in the first 25 days. It correlated with low birth weight (p<0.001), with mean of 1,140g. The most frequent alterations were white soft plaques, detachable, in oral mucosa and tongue. Intense oral colonization by Candida spp was observed (80%). CONCLUSIONS: The frequency of invasive candidiasis was low and correlated with low birth weight and prolonged hospital stay. The most common oral changes were white plaques compatible with pseudomembranous candidiasis and colonization by Candida spp. was above average. Instituto Israelita de Ensino e Pesquisa Albert Einstein 2013 /pmc/articles/PMC4872971/ /pubmed/23579747 http://dx.doi.org/10.1590/S1679-45082013000100013 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Tinoco-Araujo, José Endrigo Araújo, Diana Ferreira Gadelha Barbosa, Patrícia Gomes Santos, Paulo Sérgio da Silva de Medeiros, Ana Myriam Costa Invasive candidiasis and oral manifestations in premature newborns |
title | Invasive candidiasis and oral manifestations in premature newborns |
title_full | Invasive candidiasis and oral manifestations in premature newborns |
title_fullStr | Invasive candidiasis and oral manifestations in premature newborns |
title_full_unstemmed | Invasive candidiasis and oral manifestations in premature newborns |
title_short | Invasive candidiasis and oral manifestations in premature newborns |
title_sort | invasive candidiasis and oral manifestations in premature newborns |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872971/ https://www.ncbi.nlm.nih.gov/pubmed/23579747 http://dx.doi.org/10.1590/S1679-45082013000100013 |
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