MEK Inhibition Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells to Dexamethasone through Modulation of mTOR Activity and Stimulation of Autophagy

Resistance to glucocorticosteroids (GCs) is a major adverse prognostic factor in B-ALL, but the molecular mechanisms leading to GC resistance are not completely understood. Herein, we sought to elucidate the molecular background of GC resistance in B-ALL and characterize the therapeutic potential of...

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Detalles Bibliográficos
Autores principales: Polak, Anna, Kiliszek, Przemysław, Sewastianik, Tomasz, Szydłowski, Maciej, Jabłońska, Ewa, Białopiotrowicz, Emilia, Górniak, Patryk, Markowicz, Sergiusz, Nowak, Eliza, Grygorowicz, Monika A., Prochorec-Sobieszek, Monika, Nowis, Dominika, Gołąb, Jakub, Giebel, Sebastian, Lech-Marańda, Ewa, Warzocha, Krzysztof, Juszczyński, Przemysław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872998/
https://www.ncbi.nlm.nih.gov/pubmed/27196001
http://dx.doi.org/10.1371/journal.pone.0155893

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