Surgical Stress Abrogates Pre-Existing Protective T Cell Mediated Anti-Tumor Immunity Leading to Postoperative Cancer Recurrence

Anti-tumor CD8(+) T cells are a key determinant for overall survival in patients following surgical resection for solid malignancies. Using a mouse model of cancer vaccination (adenovirus expressing melanoma tumor-associated antigen (TAA)—dopachrome tautomerase (AdDCT) and resection resulting in maj...

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Detalles Bibliográficos
Autores principales: Ananth, Abhirami A., Tai, Lee-Hwa, Lansdell, Casey, Alkayyal, Almohanad A., Baxter, Katherine E., Angka, Leonard, Zhang, Jiqing, Tanese de Souza, Christiano, Stephenson, Kyle B., Parato, Kelley, Bramson, Jonathan L., Bell, John C., Lichty, Brian D., Auer, Rebecca C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873120/
https://www.ncbi.nlm.nih.gov/pubmed/27196057
http://dx.doi.org/10.1371/journal.pone.0155947

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