Overcoming Resistance of Cancer Cells to PARP-1 Inhibitors with Three Different Drug Combinations

Inhibitors of poly[ADP-ribose] polymerase 1 (PARPis) show promise for treatment of cancers which lack capacity for homologous recombination repair (HRR). However, new therapeutic strategies are required in order to overcome innate and acquired resistance to these drugs and thus expand the array of c...

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Detalles Bibliográficos
Autores principales: Yalon, Michal, Tuval-Kochen, Liron, Castel, David, Moshe, Itai, Mazal, Inbal, Cohen, Osher, Avivi, Camila, Rosenblatt, Kineret, Aviel-Ronen, Sarit, Schiby, Ginette, Yahalom, Joachim, Amariglio, Ninette, Pfeffer, Raphael, Lawrence, Yaacov, Toren, Amos, Rechavi, Gideon, Paglin, Shoshana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873128/
https://www.ncbi.nlm.nih.gov/pubmed/27196668
http://dx.doi.org/10.1371/journal.pone.0155711

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