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Comparison of mHTT Antibodies in Huntington’s Disease Mouse Models Reveal Specific Binding Profiles and Steady-State Ubiquitin Levels with Disease Development

Huntington’s disease (HD) cellular pathology is characterised by the aggregation of mutant huntingtin (mHTT) protein into inclusion bodies. The present paper compared the sensitivity of five widely used mHTT antibodies (S830; MW8; EM48; 1C2; ubiquitin) against mice from five commonly used HD mouse m...

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Detalles Bibliográficos
Autores principales:	Bayram-Weston, Zubeyde, Jones, Lesley, Dunnett, Stephen B., Brooks, Simon P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873140/ https://www.ncbi.nlm.nih.gov/pubmed/27196694 http://dx.doi.org/10.1371/journal.pone.0155834

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