Cargando…

Comparison of mHTT Antibodies in Huntington’s Disease Mouse Models Reveal Specific Binding Profiles and Steady-State Ubiquitin Levels with Disease Development

Huntington’s disease (HD) cellular pathology is characterised by the aggregation of mutant huntingtin (mHTT) protein into inclusion bodies. The present paper compared the sensitivity of five widely used mHTT antibodies (S830; MW8; EM48; 1C2; ubiquitin) against mice from five commonly used HD mouse m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bayram-Weston, Zubeyde, Jones, Lesley, Dunnett, Stephen B., Brooks, Simon P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873140/ https://www.ncbi.nlm.nih.gov/pubmed/27196694 http://dx.doi.org/10.1371/journal.pone.0155834

Ejemplares similares

Developmental Trajectory of Height, Weight, and BMI in Children and Adolescents at Risk for Huntington’s Disease: Effect of mHTT on Growth
por: Tereshchenko, Alexander, et al.
Publicado: (2020)

Optimising Golgi–Cox staining for use with perfusion-fixed brain tissue validated in the zQ175 mouse model of Huntington's disease
por: Bayram-Weston, Zubeyde, et al.
Publicado: (2016)

Reduction in PA28αβ activation in HD mouse brain correlates to increased mHTT aggregation in cell models
por: Geijtenbeek, Karlijne W., et al.
Publicado: (2022)

C57BL/6 Background Attenuates mHTT Toxicity in the Striatum of YAC128 Mice
por: Back, Michaela K., et al.
Publicado: (2021)

Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington’s disease are not reflected in mutant Huntingtin inclusion prevalence
por: Bayram-Weston, Zubeyde, et al.
Publicado: (2015)

HTT haplogroups in Finnish patients with Huntington disease
por: Ylönen, Susanna, et al.
Publicado: (2019)

A novel and accurate full-length HTT mouse model for Huntington’s disease
por: Shenoy, Sushila A, et al.
Publicado: (2022)

FAN1 modifies Huntington’s disease progression by stabilizing the expanded HTT CAG repeat
por: Goold, Robert, et al.
Publicado: (2019)

Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.Htt(Q111/+) model of Huntington’s disease
por: Bragg, Robert M., et al.
Publicado: (2017)

Corrigendum: Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.Htt(Q111/+) model of Huntington’s disease
por: Bragg, Robert M., et al.
Publicado: (2017)

Alternative processing of human HTT mRNA with implications for Huntington’s disease therapeutics
por: Fienko, Sandra, et al.
Publicado: (2022)

Cognitive training modifies disease symptoms in a mouse model of Huntington's disease
por: Yhnell, Emma, et al.
Publicado: (2016)

Huntington’s Disease—An Outlook on the Interplay of the HTT Protein, Microtubules and Actin Cytoskeletal Components
por: Taran, Aleksandra S., et al.
Publicado: (2020)

In silico designing of putative peptides for targeting pathological protein Htt in Huntington's disease
por: Kohli, Harleen, et al.
Publicado: (2021)

Functional Characterisation of the Circular RNA, circHTT(2-6), in Huntington’s Disease
por: Gantley, Laura, et al.
Publicado: (2023)

A Longitudinal Motor Characterisation of the Hdh(Q111) Mouse Model of Huntington’s Disease
por: Yhnell, Emma, et al.
Publicado: (2016)

The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients
por: Neueder, Andreas, et al.
Publicado: (2017)

A Longitudinal Operant Assessment of Cognitive and Behavioural Changes in the Hdh(Q111) Mouse Model of Huntington’s Disease
por: Yhnell, Emma, et al.
Publicado: (2016)

Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.Htt(Q111/+) mouse model of Huntington’s disease
por: Coffey, Sydney R., et al.
Publicado: (2017)

SMAD transcription factors are altered in cell models of HD and regulate HTT expression
por: Bowles, KR, et al.
Publicado: (2017)

Targeting Gpr52 lowers mutant HTT levels and rescues Huntington’s disease-associated phenotypes
por: Song, Haikun, et al.
Publicado: (2018)

Integrated analysis on transcriptome and behaviors defines HTT repeat-dependent network modules in Huntington's disease
por: Huang, Lulin, et al.
Publicado: (2021)

Longitudinal in vivo MRI in a Huntington’s disease mouse model: Global atrophy in the absence of white matter microstructural damage
por: Steventon, Jessica J., et al.
Publicado: (2016)

AAV5-miHTT Gene Therapy Demonstrates Sustained Huntingtin Lowering and Functional Improvement in Huntington Disease Mouse Models
por: Spronck, Elisabeth A., et al.
Publicado: (2019)

Parkinsonism with a Hint of Huntington’s from 29 CAG Repeats in HTT
por: JOT, Sipilä
Publicado: (2019)

The utilisation of operant delayed matching and non-matching to position for probing cognitive flexibility and working memory in mouse models of Huntington's disease
por: Yhnell, Emma, et al.
Publicado: (2016)

Frequency of the loss of CAA interruption in the HTT CAG tract and implications for Huntington disease in the reduced penetrance range
por: Findlay Black, Hailey, et al.
Publicado: (2020)

An alternative splicing modulator decreases mutant HTT and improves the molecular fingerprint in Huntington’s disease patient neurons
por: Krach, Florian, et al.
Publicado: (2022)

Intrastriatal Administration of AAV5-miHTT in Non-Human Primates and Rats Is Well Tolerated and Results in miHTT Transgene Expression in Key Areas of Huntington Disease Pathology
por: Spronck, Elisabeth A., et al.
Publicado: (2021)

Characterization of HTT Inclusion Size, Location, and Timing in the zQ175 Mouse Model of Huntington´s Disease: An In Vivo High-Content Imaging Study
por: Carty, Nikisha, et al.
Publicado: (2015)

Identification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT
por: Ayala Mariscal, S. M., et al.
Publicado: (2022)

Observing Huntington’s Disease: the European Huntington’s Disease Network’s REGISTRY
por: Orth, Michael, et al.
Publicado: (2011)

The Ubiquitin-Proteasome Pathway in Huntington's Disease
por: Mitra, Siddhartha, et al.
Publicado: (2008)

Strategies to Investigate Ubiquitination in Huntington's Disease
por: Sap, Karen A., et al.
Publicado: (2020)

Ubiquitin-modifying enzymes in Huntington’s disease
por: Sap, Karen A., et al.
Publicado: (2023)

Htt(Q111/+) Huntington’s Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction
por: Kovalenko, Marina, et al.
Publicado: (2018)

Spanish HTT gene study reveals haplotype and allelic diversity with possible implications for germline expansion dynamics in Huntington disease
por: Ruiz de Sabando, Ainara, et al.
Publicado: (2022)

Excess Rab4 rescues synaptic and behavioral dysfunction caused by defective HTT-Rab4 axonal transport in Huntington’s disease
por: White, Joseph A., et al.
Publicado: (2020)

Ubiquitin–proteasome system involvement in Huntington’s disease
por: Ortega, Zaira, et al.
Publicado: (2014)

Robust Preimplantation Genetic Testing of Huntington Disease by Combined Triplet-Primed PCR Analysis of the HTT CAG Repeat and Multi-Microsatellite Haplotyping
por: Zhao, Mingjue, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_vahh5090i1djn83l9qa1h6jfru