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Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8 T cell differentiation
The asymmetric partitioning of fate determining proteins has been shown to contribute to the generation of effector and memory CD8(+) T cell precursors. Here, we demonstrate the asymmetric partitioning of mTORC1 activity upon activation of naïve CD8(+) T cells. This results in the generation of one...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873361/ https://www.ncbi.nlm.nih.gov/pubmed/27064374 http://dx.doi.org/10.1038/ni.3438 |