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Use of Cyclosporine Therapy in Steroid Resistant Nephrotic Syndrome (SRNS): A Review

A chronic, progressive disorder Steroid Resistant Nephrotic Syndrome (SRNS) accounts for 10-20% of all children with Nephrotic Syndrome. It is a heterogeneous disorder comprised of persistent edema, proteinuria, hypoalbuminemia and hyperlipidemia. Treatment for steroid-resistant nephrotic syndrome (...

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Autores principales: Shah, Syed Raza, Altaf, Areeba, Arshad, Mohammad Hussham, Mari, Anum, Noorani, Sahir, Saeed, Eraj, Mevawalla, Areesh Amir, Haq, Zaiyn Ul, Faquih, Muhammad Ehsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Canadian Center of Science and Education 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873588/
https://www.ncbi.nlm.nih.gov/pubmed/26573045
http://dx.doi.org/10.5539/gjhs.v8n4p136
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author Shah, Syed Raza
Altaf, Areeba
Arshad, Mohammad Hussham
Mari, Anum
Noorani, Sahir
Saeed, Eraj
Mevawalla, Areesh Amir
Haq, Zaiyn Ul
Faquih, Muhammad Ehsan
author_facet Shah, Syed Raza
Altaf, Areeba
Arshad, Mohammad Hussham
Mari, Anum
Noorani, Sahir
Saeed, Eraj
Mevawalla, Areesh Amir
Haq, Zaiyn Ul
Faquih, Muhammad Ehsan
author_sort Shah, Syed Raza
collection PubMed
description A chronic, progressive disorder Steroid Resistant Nephrotic Syndrome (SRNS) accounts for 10-20% of all children with Nephrotic Syndrome. It is a heterogeneous disorder comprised of persistent edema, proteinuria, hypoalbuminemia and hyperlipidemia. Treatment for steroid-resistant nephrotic syndrome (SRNS) is challenging and children who suffer from SRNS require aggressive treatment to achieve remission. Calcineurin inhibitors have been used more in an empirical manner than on the basis of clear rationale. It was in 1984 when cyclosporine was first considered for the treatment of steroid resistant nephrotic syndrome. Cyclosporin is a calcineurin inhibitor that suppresses immune response by downregulating the transcription of various cytokine genes. Till now many studies have been conducted to determine dosages, duration of therapy, side effects and advantages of cyclosporine. Treatment of SRNS remains a difficult challenge in pediatric nephrology. Treatment should be individualized according to the underlying histopathology, and clinical and environmental conditions of the children. There is an urgent need to distinguish as soon as possible those patients who may benefit from prolonged immunosuppressive treatment from those who will not benefit from such treatment and who will just suffer from its major side effects. The emerging evidence that the majority of genetic forms of SRNS should receive symptomatic treatment only, should also be clinically tested and studies baring its significance should be evaluated in the future.
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spelling pubmed-48735882016-05-26 Use of Cyclosporine Therapy in Steroid Resistant Nephrotic Syndrome (SRNS): A Review Shah, Syed Raza Altaf, Areeba Arshad, Mohammad Hussham Mari, Anum Noorani, Sahir Saeed, Eraj Mevawalla, Areesh Amir Haq, Zaiyn Ul Faquih, Muhammad Ehsan Glob J Health Sci Articles A chronic, progressive disorder Steroid Resistant Nephrotic Syndrome (SRNS) accounts for 10-20% of all children with Nephrotic Syndrome. It is a heterogeneous disorder comprised of persistent edema, proteinuria, hypoalbuminemia and hyperlipidemia. Treatment for steroid-resistant nephrotic syndrome (SRNS) is challenging and children who suffer from SRNS require aggressive treatment to achieve remission. Calcineurin inhibitors have been used more in an empirical manner than on the basis of clear rationale. It was in 1984 when cyclosporine was first considered for the treatment of steroid resistant nephrotic syndrome. Cyclosporin is a calcineurin inhibitor that suppresses immune response by downregulating the transcription of various cytokine genes. Till now many studies have been conducted to determine dosages, duration of therapy, side effects and advantages of cyclosporine. Treatment of SRNS remains a difficult challenge in pediatric nephrology. Treatment should be individualized according to the underlying histopathology, and clinical and environmental conditions of the children. There is an urgent need to distinguish as soon as possible those patients who may benefit from prolonged immunosuppressive treatment from those who will not benefit from such treatment and who will just suffer from its major side effects. The emerging evidence that the majority of genetic forms of SRNS should receive symptomatic treatment only, should also be clinically tested and studies baring its significance should be evaluated in the future. Canadian Center of Science and Education 2016-04 2015-08-06 /pmc/articles/PMC4873588/ /pubmed/26573045 http://dx.doi.org/10.5539/gjhs.v8n4p136 Text en Copyright: © Canadian Center of Science and Education http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Articles
Shah, Syed Raza
Altaf, Areeba
Arshad, Mohammad Hussham
Mari, Anum
Noorani, Sahir
Saeed, Eraj
Mevawalla, Areesh Amir
Haq, Zaiyn Ul
Faquih, Muhammad Ehsan
Use of Cyclosporine Therapy in Steroid Resistant Nephrotic Syndrome (SRNS): A Review
title Use of Cyclosporine Therapy in Steroid Resistant Nephrotic Syndrome (SRNS): A Review
title_full Use of Cyclosporine Therapy in Steroid Resistant Nephrotic Syndrome (SRNS): A Review
title_fullStr Use of Cyclosporine Therapy in Steroid Resistant Nephrotic Syndrome (SRNS): A Review
title_full_unstemmed Use of Cyclosporine Therapy in Steroid Resistant Nephrotic Syndrome (SRNS): A Review
title_short Use of Cyclosporine Therapy in Steroid Resistant Nephrotic Syndrome (SRNS): A Review
title_sort use of cyclosporine therapy in steroid resistant nephrotic syndrome (srns): a review
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873588/
https://www.ncbi.nlm.nih.gov/pubmed/26573045
http://dx.doi.org/10.5539/gjhs.v8n4p136
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