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An examination of racial differences in 5‐year survival of cervical cancer among African American and white American women in the southeastern US from 1985 to 2010

Disparities in Cervical Cancer (CC) mortality outcomes between African American (AA) and White women have been studied for decades. However, conclusions about the effect of race on CC survival differ across studies. This study assessed differences in CC survival between AA and White women diagnosed...

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Autores principales: Weragoda, Janaka, Azuero, Andres, Badiga, Suguna, Bell, Walter C., Matthews, Roland, Piyathilake, Chandrika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873605/
https://www.ncbi.nlm.nih.gov/pubmed/27185053
http://dx.doi.org/10.1002/cam4.765
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author Weragoda, Janaka
Azuero, Andres
Badiga, Suguna
Bell, Walter C.
Matthews, Roland
Piyathilake, Chandrika
author_facet Weragoda, Janaka
Azuero, Andres
Badiga, Suguna
Bell, Walter C.
Matthews, Roland
Piyathilake, Chandrika
author_sort Weragoda, Janaka
collection PubMed
description Disparities in Cervical Cancer (CC) mortality outcomes between African American (AA) and White women have been studied for decades. However, conclusions about the effect of race on CC survival differ across studies. This study assessed differences in CC survival between AA and White women diagnosed between 1985 and 2010 and treated at two major hospitals in the southeastern US. The study sample included 925 AA and 1192 White women diagnosed with cervical adenocarcinoma, adenosquamous cell carcinoma, or squamous cell carcinoma. Propensity score adjustment and matching were employed to compare 5‐year survival between the two racial groups. Crude comparisons suggested relevant racial differences in survival. However, the racial differences became of small magnitude after propensity‐score adjustment and in matched analyses. Nonlinear models identified age at diagnosis, cancer stage, mode of treatment, and histological subtype as the most salient characteristics predicting 5‐year survival of CC, yet these characteristics were also associated with race. Crude racial differences in survival might be partly explained by underlying differences in the characteristics of racial groups, such as age at diagnosis, histological subtype, cancer stage, and the mode of treatment. The study results highlight the need to improve access to early screening and treatment opportunities for AA women to improve posttreatment survival from CC.
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spelling pubmed-48736052016-06-02 An examination of racial differences in 5‐year survival of cervical cancer among African American and white American women in the southeastern US from 1985 to 2010 Weragoda, Janaka Azuero, Andres Badiga, Suguna Bell, Walter C. Matthews, Roland Piyathilake, Chandrika Cancer Med Cancer Prevention Disparities in Cervical Cancer (CC) mortality outcomes between African American (AA) and White women have been studied for decades. However, conclusions about the effect of race on CC survival differ across studies. This study assessed differences in CC survival between AA and White women diagnosed between 1985 and 2010 and treated at two major hospitals in the southeastern US. The study sample included 925 AA and 1192 White women diagnosed with cervical adenocarcinoma, adenosquamous cell carcinoma, or squamous cell carcinoma. Propensity score adjustment and matching were employed to compare 5‐year survival between the two racial groups. Crude comparisons suggested relevant racial differences in survival. However, the racial differences became of small magnitude after propensity‐score adjustment and in matched analyses. Nonlinear models identified age at diagnosis, cancer stage, mode of treatment, and histological subtype as the most salient characteristics predicting 5‐year survival of CC, yet these characteristics were also associated with race. Crude racial differences in survival might be partly explained by underlying differences in the characteristics of racial groups, such as age at diagnosis, histological subtype, cancer stage, and the mode of treatment. The study results highlight the need to improve access to early screening and treatment opportunities for AA women to improve posttreatment survival from CC. John Wiley and Sons Inc. 2016-05-17 /pmc/articles/PMC4873605/ /pubmed/27185053 http://dx.doi.org/10.1002/cam4.765 Text en © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Prevention
Weragoda, Janaka
Azuero, Andres
Badiga, Suguna
Bell, Walter C.
Matthews, Roland
Piyathilake, Chandrika
An examination of racial differences in 5‐year survival of cervical cancer among African American and white American women in the southeastern US from 1985 to 2010
title An examination of racial differences in 5‐year survival of cervical cancer among African American and white American women in the southeastern US from 1985 to 2010
title_full An examination of racial differences in 5‐year survival of cervical cancer among African American and white American women in the southeastern US from 1985 to 2010
title_fullStr An examination of racial differences in 5‐year survival of cervical cancer among African American and white American women in the southeastern US from 1985 to 2010
title_full_unstemmed An examination of racial differences in 5‐year survival of cervical cancer among African American and white American women in the southeastern US from 1985 to 2010
title_short An examination of racial differences in 5‐year survival of cervical cancer among African American and white American women in the southeastern US from 1985 to 2010
title_sort examination of racial differences in 5‐year survival of cervical cancer among african american and white american women in the southeastern us from 1985 to 2010
topic Cancer Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873605/
https://www.ncbi.nlm.nih.gov/pubmed/27185053
http://dx.doi.org/10.1002/cam4.765
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