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A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs
Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposi...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873617/ https://www.ncbi.nlm.nih.gov/pubmed/27157046 http://dx.doi.org/10.1016/j.cmet.2016.04.012 |
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| author | Raffan, Eleanor Dennis, Rowena J. O’Donovan, Conor J. Becker, Julia M. Scott, Robert A. Smith, Stephen P. Withers, David J. Wood, Claire J. Conci, Elena Clements, Dylan N. Summers, Kim M. German, Alexander J. Mellersh, Cathryn S. Arendt, Maja L. Iyemere, Valentine P. Withers, Elaine Söder, Josefin Wernersson, Sara Andersson, Göran Lindblad-Toh, Kerstin Yeo, Giles S.H. O’Rahilly, Stephen |
| author_facet | Raffan, Eleanor Dennis, Rowena J. O’Donovan, Conor J. Becker, Julia M. Scott, Robert A. Smith, Stephen P. Withers, David J. Wood, Claire J. Conci, Elena Clements, Dylan N. Summers, Kim M. German, Alexander J. Mellersh, Cathryn S. Arendt, Maja L. Iyemere, Valentine P. Withers, Elaine Söder, Josefin Wernersson, Sara Andersson, Göran Lindblad-Toh, Kerstin Yeo, Giles S.H. O’Rahilly, Stephen |
| author_sort | Raffan, Eleanor |
| collection | PubMed |
| description | Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits. |
| format | Online Article Text |
| id | pubmed-4873617 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | Cell Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-48736172016-05-23 A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs Raffan, Eleanor Dennis, Rowena J. O’Donovan, Conor J. Becker, Julia M. Scott, Robert A. Smith, Stephen P. Withers, David J. Wood, Claire J. Conci, Elena Clements, Dylan N. Summers, Kim M. German, Alexander J. Mellersh, Cathryn S. Arendt, Maja L. Iyemere, Valentine P. Withers, Elaine Söder, Josefin Wernersson, Sara Andersson, Göran Lindblad-Toh, Kerstin Yeo, Giles S.H. O’Rahilly, Stephen Cell Metab Short Article Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits. Cell Press 2016-05-10 /pmc/articles/PMC4873617/ /pubmed/27157046 http://dx.doi.org/10.1016/j.cmet.2016.04.012 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Short Article Raffan, Eleanor Dennis, Rowena J. O’Donovan, Conor J. Becker, Julia M. Scott, Robert A. Smith, Stephen P. Withers, David J. Wood, Claire J. Conci, Elena Clements, Dylan N. Summers, Kim M. German, Alexander J. Mellersh, Cathryn S. Arendt, Maja L. Iyemere, Valentine P. Withers, Elaine Söder, Josefin Wernersson, Sara Andersson, Göran Lindblad-Toh, Kerstin Yeo, Giles S.H. O’Rahilly, Stephen A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs |
| title | A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs |
| title_full | A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs |
| title_fullStr | A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs |
| title_full_unstemmed | A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs |
| title_short | A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs |
| title_sort | deletion in the canine pomc gene is associated with weight and appetite in obesity-prone labrador retriever dogs |
| topic | Short Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873617/ https://www.ncbi.nlm.nih.gov/pubmed/27157046 http://dx.doi.org/10.1016/j.cmet.2016.04.012 |
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