A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposi...

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Detalles Bibliográficos
Autores principales: Raffan, Eleanor, Dennis, Rowena J., O’Donovan, Conor J., Becker, Julia M., Scott, Robert A., Smith, Stephen P., Withers, David J., Wood, Claire J., Conci, Elena, Clements, Dylan N., Summers, Kim M., German, Alexander J., Mellersh, Cathryn S., Arendt, Maja L., Iyemere, Valentine P., Withers, Elaine, Söder, Josefin, Wernersson, Sara, Andersson, Göran, Lindblad-Toh, Kerstin, Yeo, Giles S.H., O’Rahilly, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873617/
https://www.ncbi.nlm.nih.gov/pubmed/27157046
http://dx.doi.org/10.1016/j.cmet.2016.04.012

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