Mapping the Human Platelet Lipidome Reveals Cytosolic Phospholipase A(2) as a Regulator of Mitochondrial Bioenergetics during Activation

Human platelets acutely increase mitochondrial energy generation following stimulation. Herein, a lipidomic circuit was uncovered whereby the substrates for this are exclusively provided by cPLA(2), including multiple fatty acids and oxidized species that support energy generation via β-oxidation. T...

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Detalles Bibliográficos
Autores principales: Slatter, David A., Aldrovandi, Maceler, O’Connor, Anne, Allen, Stuart M., Brasher, Christopher J., Murphy, Robert C., Mecklemann, Sven, Ravi, Saranya, Darley-Usmar, Victor, O’Donnell, Valerie B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873619/
https://www.ncbi.nlm.nih.gov/pubmed/27133131
http://dx.doi.org/10.1016/j.cmet.2016.04.001

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