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Outcome of operable oral cavity cancer and impact of maintenance metronomic chemotherapy: A retrospective study from rural India
BACKGROUND: Oral cavity cancer is the most common cancer among rural India. There is a paucity of data for outcomes of operable oral cavity cancer from rural India. Use of maintenance metronomic may delay or avoid relapse. AIM: To evaluate outcomes of operable oral cavity carcinoma and evaluate impa...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873695/ https://www.ncbi.nlm.nih.gov/pubmed/27275446 http://dx.doi.org/10.4103/2278-330X.181625 |
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author | Pandey, Avinash Desai, A. Ostwal, V. Patil, V. Kulkarni, A. Kulkarni, R. Patil, N. Chaukar, D. Prabhash, K. Banavali, Shripad D. |
author_facet | Pandey, Avinash Desai, A. Ostwal, V. Patil, V. Kulkarni, A. Kulkarni, R. Patil, N. Chaukar, D. Prabhash, K. Banavali, Shripad D. |
author_sort | Pandey, Avinash |
collection | PubMed |
description | BACKGROUND: Oral cavity cancer is the most common cancer among rural India. There is a paucity of data for outcomes of operable oral cavity cancer from rural India. Use of maintenance metronomic may delay or avoid relapse. AIM: To evaluate outcomes of operable oral cavity carcinoma and evaluate impact of maintenance metronomic chemotherapy. OBJECTIVES: To evaluate disease-free survival (DFS), overall survival (OS), and factors affecting the outcome in operable oral cavity cancer. MATERIALS AND METHODS: Data of patients diagnosed with oral cavity cancer registered between May 2008 and May 2014 were retrieved. Only those patients with operable oral cavity cancer and upfront definitive surgery were included in the study. Demographic profile, stage, tobacco consumption, adjuvant therapy, and pattern of failure were collected. Kaplan–Meir survival analysis was used to determine DFS and OS. Log-rank test was used to evaluate factors affecting outcome. RESULTS: Median follow-up is 24 months. Out of 335 patients, 225 (67%) had advanced operable cancer with 42/225 (18%) and 183/225 (82%) as Stages III and IVA, respectively. Buccal mucosa was the most common subsite (178/335, 53%) followed by tongue (63/335, 19%). Ninety-two percent patients were addicted to smokeless tobacco, whereas 27% were smokers. Median DFS is 13 months with 2 years relative DFS 32%. Median OS is 30 months, with 2 years OS of 54%. Metronomic adjuvant oral chemotherapy was given in 130/225 (58%); Stage III and IVA patients with median of 14 months (3–18 months). Use of metronomic chemotherapy improved DFS (8 vs. 14 months, P = 0.22) and OS (14 vs. 26 months, P = 0.04). CONCLUSION: Oral cavity cancer is a major health care problem in rural India. Presentation at advanced stage leads to suboptimal outcomes. Benefit of metronomic maintenance chemotherapy in locally advanced oral cavity needs to be further evaluated prospectively. |
format | Online Article Text |
id | pubmed-4873695 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-48736952016-06-06 Outcome of operable oral cavity cancer and impact of maintenance metronomic chemotherapy: A retrospective study from rural India Pandey, Avinash Desai, A. Ostwal, V. Patil, V. Kulkarni, A. Kulkarni, R. Patil, N. Chaukar, D. Prabhash, K. Banavali, Shripad D. South Asian J Cancer METRONOMIC THERAPY IN HEAD AND NECK CANCERS: Original Article BACKGROUND: Oral cavity cancer is the most common cancer among rural India. There is a paucity of data for outcomes of operable oral cavity cancer from rural India. Use of maintenance metronomic may delay or avoid relapse. AIM: To evaluate outcomes of operable oral cavity carcinoma and evaluate impact of maintenance metronomic chemotherapy. OBJECTIVES: To evaluate disease-free survival (DFS), overall survival (OS), and factors affecting the outcome in operable oral cavity cancer. MATERIALS AND METHODS: Data of patients diagnosed with oral cavity cancer registered between May 2008 and May 2014 were retrieved. Only those patients with operable oral cavity cancer and upfront definitive surgery were included in the study. Demographic profile, stage, tobacco consumption, adjuvant therapy, and pattern of failure were collected. Kaplan–Meir survival analysis was used to determine DFS and OS. Log-rank test was used to evaluate factors affecting outcome. RESULTS: Median follow-up is 24 months. Out of 335 patients, 225 (67%) had advanced operable cancer with 42/225 (18%) and 183/225 (82%) as Stages III and IVA, respectively. Buccal mucosa was the most common subsite (178/335, 53%) followed by tongue (63/335, 19%). Ninety-two percent patients were addicted to smokeless tobacco, whereas 27% were smokers. Median DFS is 13 months with 2 years relative DFS 32%. Median OS is 30 months, with 2 years OS of 54%. Metronomic adjuvant oral chemotherapy was given in 130/225 (58%); Stage III and IVA patients with median of 14 months (3–18 months). Use of metronomic chemotherapy improved DFS (8 vs. 14 months, P = 0.22) and OS (14 vs. 26 months, P = 0.04). CONCLUSION: Oral cavity cancer is a major health care problem in rural India. Presentation at advanced stage leads to suboptimal outcomes. Benefit of metronomic maintenance chemotherapy in locally advanced oral cavity needs to be further evaluated prospectively. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4873695/ /pubmed/27275446 http://dx.doi.org/10.4103/2278-330X.181625 Text en Copyright: © South Asian Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | METRONOMIC THERAPY IN HEAD AND NECK CANCERS: Original Article Pandey, Avinash Desai, A. Ostwal, V. Patil, V. Kulkarni, A. Kulkarni, R. Patil, N. Chaukar, D. Prabhash, K. Banavali, Shripad D. Outcome of operable oral cavity cancer and impact of maintenance metronomic chemotherapy: A retrospective study from rural India |
title | Outcome of operable oral cavity cancer and impact of maintenance metronomic chemotherapy: A retrospective study from rural India |
title_full | Outcome of operable oral cavity cancer and impact of maintenance metronomic chemotherapy: A retrospective study from rural India |
title_fullStr | Outcome of operable oral cavity cancer and impact of maintenance metronomic chemotherapy: A retrospective study from rural India |
title_full_unstemmed | Outcome of operable oral cavity cancer and impact of maintenance metronomic chemotherapy: A retrospective study from rural India |
title_short | Outcome of operable oral cavity cancer and impact of maintenance metronomic chemotherapy: A retrospective study from rural India |
title_sort | outcome of operable oral cavity cancer and impact of maintenance metronomic chemotherapy: a retrospective study from rural india |
topic | METRONOMIC THERAPY IN HEAD AND NECK CANCERS: Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873695/ https://www.ncbi.nlm.nih.gov/pubmed/27275446 http://dx.doi.org/10.4103/2278-330X.181625 |
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