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A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion

Strong evidence suggests that phospholipase Cγ1 (PLCγ1) is a suitable target to counteract tumourigenesis and metastasis dissemination. We recently identified a novel signalling pathway required for PLCγ1 activation which involves formation of a protein complex with 3-phosphoinositide-dependent prot...

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Detalles Bibliográficos
Autores principales:	Raimondi, Claudio, Calleja, Veronique, Ferro, Riccardo, Fantin, Alessandro, Riley, Andrew M., Potter, Barry V. L., Brennan, Caroline H., Maffucci, Tania, Larijani, Banafshé, Falasca, Marco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873738/ https://www.ncbi.nlm.nih.gov/pubmed/27199173 http://dx.doi.org/10.1038/srep26142

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