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Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats

Both exercise and calorie restriction interventions have been recommended for inducing weight-loss in obese states. However, there is conflicting evidence on their relative benefits for metabolic health and insulin sensitivity. This study seeks to evaluate the differential effects of the two interve...

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Autores principales: Gopalan, Venkatesh, Michael, Navin, Ishino, Seigo, Lee, Swee Shean, Yang, Adonsia Yating, Bhanu Prakash, K. N., Yaligar, Jadegoud, Sadananthan, Suresh Anand, Kaneko, Manami, Zhou, Zhihong, Satomi, Yoshinori, Hirayama, Megumi, Kamiguchi, Hidenori, Zhu, Bin, Horiguchi, Takashi, Nishimoto, Tomoyuki, Velan, S. Sendhil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873816/
https://www.ncbi.nlm.nih.gov/pubmed/27197769
http://dx.doi.org/10.1038/srep26445
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author Gopalan, Venkatesh
Michael, Navin
Ishino, Seigo
Lee, Swee Shean
Yang, Adonsia Yating
Bhanu Prakash, K. N.
Yaligar, Jadegoud
Sadananthan, Suresh Anand
Kaneko, Manami
Zhou, Zhihong
Satomi, Yoshinori
Hirayama, Megumi
Kamiguchi, Hidenori
Zhu, Bin
Horiguchi, Takashi
Nishimoto, Tomoyuki
Velan, S. Sendhil
author_facet Gopalan, Venkatesh
Michael, Navin
Ishino, Seigo
Lee, Swee Shean
Yang, Adonsia Yating
Bhanu Prakash, K. N.
Yaligar, Jadegoud
Sadananthan, Suresh Anand
Kaneko, Manami
Zhou, Zhihong
Satomi, Yoshinori
Hirayama, Megumi
Kamiguchi, Hidenori
Zhu, Bin
Horiguchi, Takashi
Nishimoto, Tomoyuki
Velan, S. Sendhil
author_sort Gopalan, Venkatesh
collection PubMed
description Both exercise and calorie restriction interventions have been recommended for inducing weight-loss in obese states. However, there is conflicting evidence on their relative benefits for metabolic health and insulin sensitivity. This study seeks to evaluate the differential effects of the two interventions on fat mobilization, fat metabolism, and insulin sensitivity in diet-induced obese animal models. After 4 months of ad libitum high fat diet feeding, 35 male Fischer F344 rats were grouped (n = 7 per cohort) into sedentary control (CON), exercise once a day (EX1), exercise twice a day (EX2), 15% calorie restriction (CR1) and 30% calorie restriction (CR2) cohorts. Interventions were carried out over a 4-week period. We found elevated hepatic and muscle long chain acylcarnitines with both exercise and calorie restriction, and a positive association between hepatic long chain acylcarnitines and insulin sensitivity in the pooled cohort. Our result suggests that long chain acylcarnitines may not indicate incomplete fat oxidation in weight loss interventions. Calorie restriction was found to be more effective than exercise in reducing body weight. Exercise, on the other hand, was more effective in reducing adipose depots and muscle triglycerides, favorably altering muscle/liver desaturase activity and improving insulin sensitivity.
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spelling pubmed-48738162016-06-02 Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats Gopalan, Venkatesh Michael, Navin Ishino, Seigo Lee, Swee Shean Yang, Adonsia Yating Bhanu Prakash, K. N. Yaligar, Jadegoud Sadananthan, Suresh Anand Kaneko, Manami Zhou, Zhihong Satomi, Yoshinori Hirayama, Megumi Kamiguchi, Hidenori Zhu, Bin Horiguchi, Takashi Nishimoto, Tomoyuki Velan, S. Sendhil Sci Rep Article Both exercise and calorie restriction interventions have been recommended for inducing weight-loss in obese states. However, there is conflicting evidence on their relative benefits for metabolic health and insulin sensitivity. This study seeks to evaluate the differential effects of the two interventions on fat mobilization, fat metabolism, and insulin sensitivity in diet-induced obese animal models. After 4 months of ad libitum high fat diet feeding, 35 male Fischer F344 rats were grouped (n = 7 per cohort) into sedentary control (CON), exercise once a day (EX1), exercise twice a day (EX2), 15% calorie restriction (CR1) and 30% calorie restriction (CR2) cohorts. Interventions were carried out over a 4-week period. We found elevated hepatic and muscle long chain acylcarnitines with both exercise and calorie restriction, and a positive association between hepatic long chain acylcarnitines and insulin sensitivity in the pooled cohort. Our result suggests that long chain acylcarnitines may not indicate incomplete fat oxidation in weight loss interventions. Calorie restriction was found to be more effective than exercise in reducing body weight. Exercise, on the other hand, was more effective in reducing adipose depots and muscle triglycerides, favorably altering muscle/liver desaturase activity and improving insulin sensitivity. Nature Publishing Group 2016-05-20 /pmc/articles/PMC4873816/ /pubmed/27197769 http://dx.doi.org/10.1038/srep26445 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Gopalan, Venkatesh
Michael, Navin
Ishino, Seigo
Lee, Swee Shean
Yang, Adonsia Yating
Bhanu Prakash, K. N.
Yaligar, Jadegoud
Sadananthan, Suresh Anand
Kaneko, Manami
Zhou, Zhihong
Satomi, Yoshinori
Hirayama, Megumi
Kamiguchi, Hidenori
Zhu, Bin
Horiguchi, Takashi
Nishimoto, Tomoyuki
Velan, S. Sendhil
Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats
title Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats
title_full Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats
title_fullStr Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats
title_full_unstemmed Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats
title_short Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats
title_sort effect of exercise and calorie restriction on tissue acylcarnitines, tissue desaturase indices, and fat accumulation in diet-induced obese rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873816/
https://www.ncbi.nlm.nih.gov/pubmed/27197769
http://dx.doi.org/10.1038/srep26445
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