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Immunohistochemical detection of a potential molecular therapeutic target for canine hemangiosarcoma
Canine hemangiosarcoma (HSA) is a progressive malignant neoplasm of dogs for which there is currently no effective treatment. A recent study suggested that receptor tyrosine kinases (RTKs), the PI3K/Akt/m-TOR and MAPK pathways are all activated in canine and human HSA. The aim of the present study w...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Veterinary Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873857/ https://www.ncbi.nlm.nih.gov/pubmed/26685984 http://dx.doi.org/10.1292/jvms.15-0625 |
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author | ADACHI, Mami HOSHINO, Yuki IZUMI, Yusuke TAKAGI, Satoshi |
author_facet | ADACHI, Mami HOSHINO, Yuki IZUMI, Yusuke TAKAGI, Satoshi |
author_sort | ADACHI, Mami |
collection | PubMed |
description | Canine hemangiosarcoma (HSA) is a progressive malignant neoplasm of dogs for which there is currently no effective treatment. A recent study suggested that receptor tyrosine kinases (RTKs), the PI3K/Akt/m-TOR and MAPK pathways are all activated in canine and human HSA. The aim of the present study was to investigate the overexpression of these proteins by immunohistochemistry in canine splenic HSA to identify potential molecular therapeutic targets. A total of 10 splenic HSAs and two normal splenic samples surgically resected from dogs were sectioned and stained with hematoxylin and eosin for histological diagnosis or analyzed using immunohistochemistry. The expression of RTKs, c-kit, VEGFR-2 and PDGFR-2, as well as PI3K/Akt/m-TOR and MEK was higher in canine splenic HSAs compared to normal spleens. These proteins may therefore be potential therapeutic targets in canine splenic HSA. |
format | Online Article Text |
id | pubmed-4873857 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Japanese Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-48738572016-05-25 Immunohistochemical detection of a potential molecular therapeutic target for canine hemangiosarcoma ADACHI, Mami HOSHINO, Yuki IZUMI, Yusuke TAKAGI, Satoshi J Vet Med Sci Internal Medicine Canine hemangiosarcoma (HSA) is a progressive malignant neoplasm of dogs for which there is currently no effective treatment. A recent study suggested that receptor tyrosine kinases (RTKs), the PI3K/Akt/m-TOR and MAPK pathways are all activated in canine and human HSA. The aim of the present study was to investigate the overexpression of these proteins by immunohistochemistry in canine splenic HSA to identify potential molecular therapeutic targets. A total of 10 splenic HSAs and two normal splenic samples surgically resected from dogs were sectioned and stained with hematoxylin and eosin for histological diagnosis or analyzed using immunohistochemistry. The expression of RTKs, c-kit, VEGFR-2 and PDGFR-2, as well as PI3K/Akt/m-TOR and MEK was higher in canine splenic HSAs compared to normal spleens. These proteins may therefore be potential therapeutic targets in canine splenic HSA. The Japanese Society of Veterinary Science 2015-12-21 2016-04 /pmc/articles/PMC4873857/ /pubmed/26685984 http://dx.doi.org/10.1292/jvms.15-0625 Text en ©2016 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Internal Medicine ADACHI, Mami HOSHINO, Yuki IZUMI, Yusuke TAKAGI, Satoshi Immunohistochemical detection of a potential molecular therapeutic target for canine hemangiosarcoma |
title | Immunohistochemical detection of a potential molecular therapeutic target for
canine hemangiosarcoma |
title_full | Immunohistochemical detection of a potential molecular therapeutic target for
canine hemangiosarcoma |
title_fullStr | Immunohistochemical detection of a potential molecular therapeutic target for
canine hemangiosarcoma |
title_full_unstemmed | Immunohistochemical detection of a potential molecular therapeutic target for
canine hemangiosarcoma |
title_short | Immunohistochemical detection of a potential molecular therapeutic target for
canine hemangiosarcoma |
title_sort | immunohistochemical detection of a potential molecular therapeutic target for
canine hemangiosarcoma |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873857/ https://www.ncbi.nlm.nih.gov/pubmed/26685984 http://dx.doi.org/10.1292/jvms.15-0625 |
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