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Selenium supplementation restores the decreased albumin level of peripheral blood mononuclear cells in streptozotocin-induced diabetic mice
Previously, it has been suggested that the phenotypic level of albumin in peripheral blood mononuclear cells (PBMC) decreased in streptozotocin (STZ)-induced diabetic rats. Concomitantly, the production of oxidative stresses was also elevated in the diabetic PBMC compared to that of normal control....
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Veterinary Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873859/ https://www.ncbi.nlm.nih.gov/pubmed/26726102 http://dx.doi.org/10.1292/jvms.15-0611 |
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author | AHN, Taeho BAE, Chun-Sik YUN, Chul-Ho |
author_facet | AHN, Taeho BAE, Chun-Sik YUN, Chul-Ho |
author_sort | AHN, Taeho |
collection | PubMed |
description | Previously, it has been suggested that the phenotypic level of albumin in peripheral blood mononuclear cells (PBMC) decreased in streptozotocin (STZ)-induced diabetic rats. Concomitantly, the production of oxidative stresses was also elevated in the diabetic PBMC compared to that of normal control. These results suggest the close relationship between PBMC-albumin and its antioxidant roles. Here, we expanded the previous studies and investigated the effect of selenium supplementation as inorganic (sodium selenate) forms on the levels of albumin expression and oxidative stress in PBMC of STZ-induced diabetic mice. Selenium intake recovered the decreased albumin levels to those of normal mice and reduced the production of reactive oxygen species (ROS). These results support that selenium intake may alleviate the etiology and pathology of PBMC in type 1 diabetic mice by restoring the decrease in albumin contents and the production of ROS. |
format | Online Article Text |
id | pubmed-4873859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Japanese Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-48738592016-05-25 Selenium supplementation restores the decreased albumin level of peripheral blood mononuclear cells in streptozotocin-induced diabetic mice AHN, Taeho BAE, Chun-Sik YUN, Chul-Ho J Vet Med Sci Biochemistry Previously, it has been suggested that the phenotypic level of albumin in peripheral blood mononuclear cells (PBMC) decreased in streptozotocin (STZ)-induced diabetic rats. Concomitantly, the production of oxidative stresses was also elevated in the diabetic PBMC compared to that of normal control. These results suggest the close relationship between PBMC-albumin and its antioxidant roles. Here, we expanded the previous studies and investigated the effect of selenium supplementation as inorganic (sodium selenate) forms on the levels of albumin expression and oxidative stress in PBMC of STZ-induced diabetic mice. Selenium intake recovered the decreased albumin levels to those of normal mice and reduced the production of reactive oxygen species (ROS). These results support that selenium intake may alleviate the etiology and pathology of PBMC in type 1 diabetic mice by restoring the decrease in albumin contents and the production of ROS. The Japanese Society of Veterinary Science 2016-01-03 2016-04 /pmc/articles/PMC4873859/ /pubmed/26726102 http://dx.doi.org/10.1292/jvms.15-0611 Text en ©2016 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Biochemistry AHN, Taeho BAE, Chun-Sik YUN, Chul-Ho Selenium supplementation restores the decreased albumin level of peripheral blood mononuclear cells in streptozotocin-induced diabetic mice |
title | Selenium supplementation restores the decreased albumin level of peripheral
blood mononuclear cells in streptozotocin-induced diabetic mice |
title_full | Selenium supplementation restores the decreased albumin level of peripheral
blood mononuclear cells in streptozotocin-induced diabetic mice |
title_fullStr | Selenium supplementation restores the decreased albumin level of peripheral
blood mononuclear cells in streptozotocin-induced diabetic mice |
title_full_unstemmed | Selenium supplementation restores the decreased albumin level of peripheral
blood mononuclear cells in streptozotocin-induced diabetic mice |
title_short | Selenium supplementation restores the decreased albumin level of peripheral
blood mononuclear cells in streptozotocin-induced diabetic mice |
title_sort | selenium supplementation restores the decreased albumin level of peripheral
blood mononuclear cells in streptozotocin-induced diabetic mice |
topic | Biochemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873859/ https://www.ncbi.nlm.nih.gov/pubmed/26726102 http://dx.doi.org/10.1292/jvms.15-0611 |
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