Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma

Feline mammary carcinomas are characterized by rapid progression and metastases. Vascular endothelial growth factor (VEGF) is a key regulator of tumor angiogenesis, proliferation and metastasis. The present study aimed to investigate the effects of a single drug therapy of bevacizumab on a xenograft...

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Autores principales: MICHISHITA, Masaki, OHTSUKA, Aya, NAKAHIRA, Rei, TAJIMA, Tsuyoshi, NAKAGAWA, Takayuki, SASAKI, Nobuo, ARAI, Toshiro, TAKAHASHI, Kimimasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2015
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873862/
https://www.ncbi.nlm.nih.gov/pubmed/26616000
http://dx.doi.org/10.1292/jvms.15-0550
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author MICHISHITA, Masaki
OHTSUKA, Aya
NAKAHIRA, Rei
TAJIMA, Tsuyoshi
NAKAGAWA, Takayuki
SASAKI, Nobuo
ARAI, Toshiro
TAKAHASHI, Kimimasa
author_facet MICHISHITA, Masaki
OHTSUKA, Aya
NAKAHIRA, Rei
TAJIMA, Tsuyoshi
NAKAGAWA, Takayuki
SASAKI, Nobuo
ARAI, Toshiro
TAKAHASHI, Kimimasa
author_sort MICHISHITA, Masaki
collection PubMed
description Feline mammary carcinomas are characterized by rapid progression and metastases. Vascular endothelial growth factor (VEGF) is a key regulator of tumor angiogenesis, proliferation and metastasis. The present study aimed to investigate the effects of a single drug therapy of bevacizumab on a xenograft model of feline mammary carcinoma expressing VEGF protein. Bevacizumab treatment suppressed tumor growth by inhibiting angiogenesis and enhancing apoptosis; however, it did not affect the tumor proliferation index. Thus, bevacizumab had anti-tumor effects on a xenograft model, and this may be useful for the treatment of feline mammary carcinoma.
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spelling pubmed-48738622016-05-25 Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma MICHISHITA, Masaki OHTSUKA, Aya NAKAHIRA, Rei TAJIMA, Tsuyoshi NAKAGAWA, Takayuki SASAKI, Nobuo ARAI, Toshiro TAKAHASHI, Kimimasa J Vet Med Sci Pharmacology Feline mammary carcinomas are characterized by rapid progression and metastases. Vascular endothelial growth factor (VEGF) is a key regulator of tumor angiogenesis, proliferation and metastasis. The present study aimed to investigate the effects of a single drug therapy of bevacizumab on a xenograft model of feline mammary carcinoma expressing VEGF protein. Bevacizumab treatment suppressed tumor growth by inhibiting angiogenesis and enhancing apoptosis; however, it did not affect the tumor proliferation index. Thus, bevacizumab had anti-tumor effects on a xenograft model, and this may be useful for the treatment of feline mammary carcinoma. The Japanese Society of Veterinary Science 2015-11-28 2016-04 /pmc/articles/PMC4873862/ /pubmed/26616000 http://dx.doi.org/10.1292/jvms.15-0550 Text en ©2016 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Pharmacology
MICHISHITA, Masaki
OHTSUKA, Aya
NAKAHIRA, Rei
TAJIMA, Tsuyoshi
NAKAGAWA, Takayuki
SASAKI, Nobuo
ARAI, Toshiro
TAKAHASHI, Kimimasa
Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma
title Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma
title_full Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma
title_fullStr Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma
title_full_unstemmed Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma
title_short Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma
title_sort anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873862/
https://www.ncbi.nlm.nih.gov/pubmed/26616000
http://dx.doi.org/10.1292/jvms.15-0550
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