Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange

Omalizumab is a widely used therapeutic anti-IgE antibody. Here we report the crystal structure of the omalizumab–Fab in complex with an IgE-Fc fragment. This structure reveals the mechanism of omalizumab-mediated inhibition of IgE interactions with both high- and low-affinity IgE receptors, and exp...

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Detalles Bibliográficos
Autores principales: Pennington, Luke F., Tarchevskaya, Svetlana, Brigger, Daniel, Sathiyamoorthy, Karthik, Graham, Michelle T., Nadeau, Kari Christine, Eggel, Alexander, Jardetzky, Theodore S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873975/
https://www.ncbi.nlm.nih.gov/pubmed/27194387
http://dx.doi.org/10.1038/ncomms11610

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