What is memory? The present state of the engram

The mechanism of memory remains one of the great unsolved problems of biology. Grappling with the question more than a hundred years ago, the German zoologist Richard Semon formulated the concept of the engram, lasting connections in the brain that result from simultaneous “excitations”, whose preci...

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Detalles Bibliográficos
Autores principales: Poo, Mu-ming, Pignatelli, Michele, Ryan, Tomás J., Tonegawa, Susumu, Bonhoeffer, Tobias, Martin, Kelsey C., Rudenko, Andrii, Tsai, Li-Huei, Tsien, Richard W., Fishell, Gord, Mullins, Caitlin, Gonçalves, J. Tiago, Shtrahman, Matthew, Johnston, Stephen T., Gage, Fred H., Dan, Yang, Long, John, Buzsáki, György, Stevens, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Forum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874022/
https://www.ncbi.nlm.nih.gov/pubmed/27197636
http://dx.doi.org/10.1186/s12915-016-0261-6
Descripción
Sumario:The mechanism of memory remains one of the great unsolved problems of biology. Grappling with the question more than a hundred years ago, the German zoologist Richard Semon formulated the concept of the engram, lasting connections in the brain that result from simultaneous “excitations”, whose precise physical nature and consequences were out of reach of the biology of his day. Neuroscientists now have the knowledge and tools to tackle this question, however, and this Forum brings together leading contemporary views on the mechanisms of memory and what the engram means today.

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