Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer

The precise molecular alterations driving castration-resistant prostate cancer (CRPC) are not clearly understood. Using a novel network-based integrative approach, here, we show distinct alterations in the hexosamine biosynthetic pathway (HBP) to be critical for CRPC. Expression of HBP enzyme glucos...

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Detalles Bibliográficos
Autores principales: Kaushik, Akash K., Shojaie, Ali, Panzitt, Katrin, Sonavane, Rajni, Venghatakrishnan, Harene, Manikkam, Mohan, Zaslavsky, Alexander, Putluri, Vasanta, Vasu, Vihas T., Zhang, Yiqing, Khan, Ayesha S., Lloyd, Stacy, Szafran, Adam T., Dasgupta, Subhamoy, Bader, David A., Stossi, Fabio, Li, Hangwen, Samanta, Susmita, Cao, Xuhong, Tsouko, Efrosini, Huang, Shixia, Frigo, Daniel E., Chan, Lawrence, Edwards, Dean P., Kaipparettu, Benny A., Mitsiades, Nicholas, Weigel, Nancy L., Mancini, Michael, McGuire, Sean E., Mehra, Rohit, Ittmann, Michael M., Chinnaiyan, Arul M., Putluri, Nagireddy, Palapattu, Ganesh S., Michailidis, George, Sreekumar, Arun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874037/
https://www.ncbi.nlm.nih.gov/pubmed/27194471
http://dx.doi.org/10.1038/ncomms11612

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