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Effect of dexamethasone in low volume supraclavicular brachial plexus block: A double-blinded randomized clinical study

BACKGROUND AND AIMS: With the use of ultrasound, a minimal effective volume of 20 ml has been described for supraclavicular brachial plexus block. However achieving a long duration of analgesia with this minimal volume remains a challenge. We aimed to determine the effect of dexamethasone on onset a...

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Autores principales: Alarasan, Arun Kumar, Agrawal, Jitendre, Choudhary, Bhanu, Melhotra, Amrita, Uike, Satyendre, Mukherji, Arghya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874081/
https://www.ncbi.nlm.nih.gov/pubmed/27275056
http://dx.doi.org/10.4103/0970-9185.182108
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author Alarasan, Arun Kumar
Agrawal, Jitendre
Choudhary, Bhanu
Melhotra, Amrita
Uike, Satyendre
Mukherji, Arghya
author_facet Alarasan, Arun Kumar
Agrawal, Jitendre
Choudhary, Bhanu
Melhotra, Amrita
Uike, Satyendre
Mukherji, Arghya
author_sort Alarasan, Arun Kumar
collection PubMed
description BACKGROUND AND AIMS: With the use of ultrasound, a minimal effective volume of 20 ml has been described for supraclavicular brachial plexus block. However achieving a long duration of analgesia with this minimal volume remains a challenge. We aimed to determine the effect of dexamethasone on onset and duration of analgesia in low volume supraclavicular brachial plexus block. MATERIAL AND METHODS: Sixty patients were randomly divided into two groups of 30 each. Group C received saline (2 ml) + 20 ml of 0.5% bupivacaine and Group D received dexamethasone (8 mg) + 20 ml of 0.5% bupivacaine in supraclavicular brachial plexus block. Hemodynamic variables and visual analog scale (VAS) score were noted at regular intervals until 450 min. The onset and duration of sensory and motor block were measured. The incidence of “Halo” around brachial plexus was observed. Student's t-test and Chi-square test were used for statistical analysis. RESULTS: The onset of sensory and motor block was significantly earlier in dexamethasone group (10.36 ± 1.99 and 12 ± 1.64) minutes compared to control group (12.9 ± 2.23 and 18.03 ± 2.41) minutes. The duration of sensory and motor block was significantly prolonged in dexamethasone group (366 ± 28.11 and 337.33 ± 28.75) minutes compared to control group (242.66 ± 26.38 and 213 ± 26.80) minutes. The VAS score was significantly lower in dexamethasone group after 210 min. “Halo” was present around the brachial plexus in all patients in both the groups. CONCLUSION: Dexamethasone addition significantly increases the duration of analgesia in patients receiving low volume supraclavicular brachial plexus block. No significant side-effects were seen in patients receiving dexamethasone as an adjunct.
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spelling pubmed-48740812016-06-06 Effect of dexamethasone in low volume supraclavicular brachial plexus block: A double-blinded randomized clinical study Alarasan, Arun Kumar Agrawal, Jitendre Choudhary, Bhanu Melhotra, Amrita Uike, Satyendre Mukherji, Arghya J Anaesthesiol Clin Pharmacol Original Article BACKGROUND AND AIMS: With the use of ultrasound, a minimal effective volume of 20 ml has been described for supraclavicular brachial plexus block. However achieving a long duration of analgesia with this minimal volume remains a challenge. We aimed to determine the effect of dexamethasone on onset and duration of analgesia in low volume supraclavicular brachial plexus block. MATERIAL AND METHODS: Sixty patients were randomly divided into two groups of 30 each. Group C received saline (2 ml) + 20 ml of 0.5% bupivacaine and Group D received dexamethasone (8 mg) + 20 ml of 0.5% bupivacaine in supraclavicular brachial plexus block. Hemodynamic variables and visual analog scale (VAS) score were noted at regular intervals until 450 min. The onset and duration of sensory and motor block were measured. The incidence of “Halo” around brachial plexus was observed. Student's t-test and Chi-square test were used for statistical analysis. RESULTS: The onset of sensory and motor block was significantly earlier in dexamethasone group (10.36 ± 1.99 and 12 ± 1.64) minutes compared to control group (12.9 ± 2.23 and 18.03 ± 2.41) minutes. The duration of sensory and motor block was significantly prolonged in dexamethasone group (366 ± 28.11 and 337.33 ± 28.75) minutes compared to control group (242.66 ± 26.38 and 213 ± 26.80) minutes. The VAS score was significantly lower in dexamethasone group after 210 min. “Halo” was present around the brachial plexus in all patients in both the groups. CONCLUSION: Dexamethasone addition significantly increases the duration of analgesia in patients receiving low volume supraclavicular brachial plexus block. No significant side-effects were seen in patients receiving dexamethasone as an adjunct. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4874081/ /pubmed/27275056 http://dx.doi.org/10.4103/0970-9185.182108 Text en Copyright: © 2016 Journal of Anaesthesiology Clinical Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Alarasan, Arun Kumar
Agrawal, Jitendre
Choudhary, Bhanu
Melhotra, Amrita
Uike, Satyendre
Mukherji, Arghya
Effect of dexamethasone in low volume supraclavicular brachial plexus block: A double-blinded randomized clinical study
title Effect of dexamethasone in low volume supraclavicular brachial plexus block: A double-blinded randomized clinical study
title_full Effect of dexamethasone in low volume supraclavicular brachial plexus block: A double-blinded randomized clinical study
title_fullStr Effect of dexamethasone in low volume supraclavicular brachial plexus block: A double-blinded randomized clinical study
title_full_unstemmed Effect of dexamethasone in low volume supraclavicular brachial plexus block: A double-blinded randomized clinical study
title_short Effect of dexamethasone in low volume supraclavicular brachial plexus block: A double-blinded randomized clinical study
title_sort effect of dexamethasone in low volume supraclavicular brachial plexus block: a double-blinded randomized clinical study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874081/
https://www.ncbi.nlm.nih.gov/pubmed/27275056
http://dx.doi.org/10.4103/0970-9185.182108
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