Out-of-hours antibiotic prescription after screening with C reactive protein: a randomised controlled study

OBJECTIVE: To evaluate the effect of preconsultation C reactive protein (CRP) screening on antibiotic prescribing and referral to hospital in Norwegian primary care settings with low prevalence of serious infections. DESIGN: Randomised controlled observational study at out-of-hours services in Norway. SETTING: Primary care. PARTICIPANTS: 401 children (0–6 years) with fever and/or respiratory symptoms were recruited from 5 different out-of-hours services (including 1 paediatric emergency clinic) in 2013–2015. INTERVENTION: Data were collected from questionnaires and clinical examination results. Every third child was randomised to a CRP test before the consultation; for the rest, the doctor ordered a CRP test if considered necessary. OUTCOME MEASURES: Main outcome variables were prescription of antibiotics and referral to hospital. RESULTS: In the group pretested with CRP, the antibiotic prescription rate was 26%, compared with 22% in the control group. In the group pretested with CRP, 5% were admitted to hospital, compared with 9% in the control group. These differences were not statistically significant. The main predictors for ordering a CRP test were parents' assessment of seriousness of the illness and the child's temperature. Paediatricians ordered CRP tests less frequently than did other doctors (9% vs 56%, p<0.001). CONCLUSIONS: Preconsultation screening with CRP of children presenting to out-of-hours services with fever and/or respiratory symptoms does not significantly affect the prescription of antibiotics or referral to hospital. TRIAL REGISTRATION NUMBER: NCT02496559; Results.