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Gelatin Microgel Incorporated Poly(ethylene glycol)-Based Bioadhesive with Enhanced Adhesive Property and Bioactivity
[Image: see text] Up to 7.5 wt % of chemically cross-linked gelatin microgel was incorporated into dopamine-modified poly(ethylene glycol) (PEGDM) adhesive to simultaneously improve the material property and bioactivity of the PEG-based bioadhesive. Incorporation of gelatin microgel reduced cure tim...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical Society
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874333/ https://www.ncbi.nlm.nih.gov/pubmed/27111631 http://dx.doi.org/10.1021/acsami.6b01364 |
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author | Li, Yuting Meng, Hao Liu, Yuan Narkar, Ameya Lee, Bruce P. |
author_facet | Li, Yuting Meng, Hao Liu, Yuan Narkar, Ameya Lee, Bruce P. |
author_sort | Li, Yuting |
collection | PubMed |
description | [Image: see text] Up to 7.5 wt % of chemically cross-linked gelatin microgel was incorporated into dopamine-modified poly(ethylene glycol) (PEGDM) adhesive to simultaneously improve the material property and bioactivity of the PEG-based bioadhesive. Incorporation of gelatin microgel reduced cure time while it increased the elastic modulus and cross-linking density of the adhesive network. Most notably, the loss modulus values for microgel-containing adhesive were an order of magnitude higher when compared to microgel-free control. This drastic increase in the viscous dissipation ability of the adhesive is attributed to the introduction of reversible physical bonds into the adhesive network with the incorporation of the gelatin microgel. Additionally, incorporation of the microgel increased the adhesive properties of PEGDM by 1.5- to 2-fold. From in vitro cell culture studies, the composite adhesive is noncytotoxic and the incorporation of microgels provided binding site for promoting fibroblast attachment and viability. The subcutaneous implantation study indicated that the microgel-containing PEGDM adhesive is biocompatible and the incorporated microgels provided pockets for rapid cellular infiltration. Gelatin microgel incorporation was demonstrated to be a facile method to simultaneously enhance the adhesive property and the bioactivity of PEG-based adhesive. |
format | Online Article Text |
id | pubmed-4874333 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | American
Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-48743332017-04-25 Gelatin Microgel Incorporated Poly(ethylene glycol)-Based Bioadhesive with Enhanced Adhesive Property and Bioactivity Li, Yuting Meng, Hao Liu, Yuan Narkar, Ameya Lee, Bruce P. ACS Appl Mater Interfaces [Image: see text] Up to 7.5 wt % of chemically cross-linked gelatin microgel was incorporated into dopamine-modified poly(ethylene glycol) (PEGDM) adhesive to simultaneously improve the material property and bioactivity of the PEG-based bioadhesive. Incorporation of gelatin microgel reduced cure time while it increased the elastic modulus and cross-linking density of the adhesive network. Most notably, the loss modulus values for microgel-containing adhesive were an order of magnitude higher when compared to microgel-free control. This drastic increase in the viscous dissipation ability of the adhesive is attributed to the introduction of reversible physical bonds into the adhesive network with the incorporation of the gelatin microgel. Additionally, incorporation of the microgel increased the adhesive properties of PEGDM by 1.5- to 2-fold. From in vitro cell culture studies, the composite adhesive is noncytotoxic and the incorporation of microgels provided binding site for promoting fibroblast attachment and viability. The subcutaneous implantation study indicated that the microgel-containing PEGDM adhesive is biocompatible and the incorporated microgels provided pockets for rapid cellular infiltration. Gelatin microgel incorporation was demonstrated to be a facile method to simultaneously enhance the adhesive property and the bioactivity of PEG-based adhesive. American Chemical Society 2016-04-25 2016-05-18 /pmc/articles/PMC4874333/ /pubmed/27111631 http://dx.doi.org/10.1021/acsami.6b01364 Text en Copyright © 2016 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Li, Yuting Meng, Hao Liu, Yuan Narkar, Ameya Lee, Bruce P. Gelatin Microgel Incorporated Poly(ethylene glycol)-Based Bioadhesive with Enhanced Adhesive Property and Bioactivity |
title | Gelatin
Microgel Incorporated Poly(ethylene glycol)-Based Bioadhesive with
Enhanced Adhesive Property and Bioactivity |
title_full | Gelatin
Microgel Incorporated Poly(ethylene glycol)-Based Bioadhesive with
Enhanced Adhesive Property and Bioactivity |
title_fullStr | Gelatin
Microgel Incorporated Poly(ethylene glycol)-Based Bioadhesive with
Enhanced Adhesive Property and Bioactivity |
title_full_unstemmed | Gelatin
Microgel Incorporated Poly(ethylene glycol)-Based Bioadhesive with
Enhanced Adhesive Property and Bioactivity |
title_short | Gelatin
Microgel Incorporated Poly(ethylene glycol)-Based Bioadhesive with
Enhanced Adhesive Property and Bioactivity |
title_sort | gelatin
microgel incorporated poly(ethylene glycol)-based bioadhesive with
enhanced adhesive property and bioactivity |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874333/ https://www.ncbi.nlm.nih.gov/pubmed/27111631 http://dx.doi.org/10.1021/acsami.6b01364 |
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