Time-resolved functional analysis of acute impairment of frataxin expression in an inducible cell model of Friedreich ataxia

Friedreich ataxia is a neurodegenerative disease caused by a GAA triplet repeat expansion in the first intron of the frataxin gene, which results in reduced expression levels of the corresponding protein. Despite numerous animal and cellular models, therapeutic options that mechanistically address i...

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Detalles Bibliográficos
Autores principales: Poburski, Dörte, Boerner, Josefine Barbara, Koenig, Michel, Ristow, Michael, Thierbach, René
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874353/
https://www.ncbi.nlm.nih.gov/pubmed/27106929
http://dx.doi.org/10.1242/bio.017004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874353/
https://www.ncbi.nlm.nih.gov/pubmed/27106929
http://dx.doi.org/10.1242/bio.017004

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