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Regulated Eukaryotic DNA Replication Origin Firing with Purified Proteins

Eukaryotic cells initiate DNA replication from multiple origins, which must be tightly regulated to promote precise genome duplication in every cell cycle. To accomplish this, initiation is partitioned into two temporally discrete steps: a double hexameric MCM complex is first loaded at replication...

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Detalles Bibliográficos
Autores principales:	Yeeles, Joseph T.P., Deegan, Tom D., Janska, Agnieszka, Early, Anne, Diffley, John F. X.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874468/ https://www.ncbi.nlm.nih.gov/pubmed/25739503 http://dx.doi.org/10.1038/nature14285

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