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Common integration sites of published datasets identified using a graph-based framework
With next-generation sequencing, the genomic data available for the characterization of integration sites (IS) has dramatically increased. At present, in a single experiment, several thousand viral integration genome targets can be investigated to define genomic hot spots. In a previous article, we...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research Network of Computational and Structural Biotechnology
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874583/ https://www.ncbi.nlm.nih.gov/pubmed/27257471 http://dx.doi.org/10.1016/j.csbj.2015.11.004 |
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author | Vasciaveo, Alessandro Velevska, Ivana Politano, Gianfranco Savino, Alessandro Schmidt, Manfred Fronza, Raffaele |
author_facet | Vasciaveo, Alessandro Velevska, Ivana Politano, Gianfranco Savino, Alessandro Schmidt, Manfred Fronza, Raffaele |
author_sort | Vasciaveo, Alessandro |
collection | PubMed |
description | With next-generation sequencing, the genomic data available for the characterization of integration sites (IS) has dramatically increased. At present, in a single experiment, several thousand viral integration genome targets can be investigated to define genomic hot spots. In a previous article, we renovated a formal CIS analysis based on a rigid fixed window demarcation into a more stretchy definition grounded on graphs. Here, we present a selection of supporting data related to the graph-based framework (GBF) from our previous article, in which a collection of common integration sites (CIS) was identified on six published datasets. In this work, we will focus on two datasets, IS(RTCGD) and IS(HIV), which have been previously discussed. Moreover, we show in more detail the workflow design that originates the datasets. |
format | Online Article Text |
id | pubmed-4874583 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Research Network of Computational and Structural Biotechnology |
record_format | MEDLINE/PubMed |
spelling | pubmed-48745832016-06-02 Common integration sites of published datasets identified using a graph-based framework Vasciaveo, Alessandro Velevska, Ivana Politano, Gianfranco Savino, Alessandro Schmidt, Manfred Fronza, Raffaele Comput Struct Biotechnol J Short Communication With next-generation sequencing, the genomic data available for the characterization of integration sites (IS) has dramatically increased. At present, in a single experiment, several thousand viral integration genome targets can be investigated to define genomic hot spots. In a previous article, we renovated a formal CIS analysis based on a rigid fixed window demarcation into a more stretchy definition grounded on graphs. Here, we present a selection of supporting data related to the graph-based framework (GBF) from our previous article, in which a collection of common integration sites (CIS) was identified on six published datasets. In this work, we will focus on two datasets, IS(RTCGD) and IS(HIV), which have been previously discussed. Moreover, we show in more detail the workflow design that originates the datasets. Research Network of Computational and Structural Biotechnology 2015-11-29 /pmc/articles/PMC4874583/ /pubmed/27257471 http://dx.doi.org/10.1016/j.csbj.2015.11.004 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Short Communication Vasciaveo, Alessandro Velevska, Ivana Politano, Gianfranco Savino, Alessandro Schmidt, Manfred Fronza, Raffaele Common integration sites of published datasets identified using a graph-based framework |
title | Common integration sites of published datasets identified using a graph-based framework |
title_full | Common integration sites of published datasets identified using a graph-based framework |
title_fullStr | Common integration sites of published datasets identified using a graph-based framework |
title_full_unstemmed | Common integration sites of published datasets identified using a graph-based framework |
title_short | Common integration sites of published datasets identified using a graph-based framework |
title_sort | common integration sites of published datasets identified using a graph-based framework |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874583/ https://www.ncbi.nlm.nih.gov/pubmed/27257471 http://dx.doi.org/10.1016/j.csbj.2015.11.004 |
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