Canine Fibroblast Growth Factor 21 Ameliorates Hyperglycemia Associated with Inhibiting Hepatic Gluconeogenesis and Improving Pancreatic Beta-Cell Survival in Diabetic Mice and Dogs

Diabetes mellitus is a common endocrinopathy in dog. Fibroblast growth factor 21 (FGF-21) is a secreted protein, which is involved in glucose homeostasis. We speculate that the recombinant canine FGF-21 (cFGF-21) has the potential to become a powerful therapeutics to treat canine diabetes. The cFGF-...

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Detalles Bibliográficos
Autores principales: Xu, Pengfei, Zhang, Yingjie, Jiang, Xinghao, Li, Junyan, Song, Liying, Khoso, Mir Hasson, Liu, Yunye, Wu, Qiang, Ren, Guiping, Li, Deshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874679/
https://www.ncbi.nlm.nih.gov/pubmed/27203422
http://dx.doi.org/10.1371/journal.pone.0155598

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