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Prevalence of neutropenia in children by nationality
BACKGROUND: A high prevalence of neutropenia has been reported in several ethnic groups amongst whom many healthy individuals with low neutrophil counts undergo unnecessary investigations. This study aims to ascertain the prevalence of neutropenia (NP) in a large cohort of children from North Africa...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875641/ https://www.ncbi.nlm.nih.gov/pubmed/27213048 http://dx.doi.org/10.1186/s12878-016-0054-8 |
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author | Denic, Srdjan Narchi, Hassib Al Mekaini, Lolowa A. Al-Hammadi, Suleiman Al Jabri, Omar N. Souid, Abdul-Kader |
author_facet | Denic, Srdjan Narchi, Hassib Al Mekaini, Lolowa A. Al-Hammadi, Suleiman Al Jabri, Omar N. Souid, Abdul-Kader |
author_sort | Denic, Srdjan |
collection | PubMed |
description | BACKGROUND: A high prevalence of neutropenia has been reported in several ethnic groups amongst whom many healthy individuals with low neutrophil counts undergo unnecessary investigations. This study aims to ascertain the prevalence of neutropenia (NP) in a large cohort of children from North African, Middle Eastern, and Asian countries residing in the United Arab Emirates. METHODS: Neutrophil counts of 26,542 children (one day to six years of age) from 86 countries were analyzed. The subjects were enrolled in the Well-Child-Care program of Ambulatory Health Services of Emirate of Abu Dhabi, United Arab Emirates. NP was defined as a neutrophil count <1.5 × 10(9)/L and severe NP <0.5 × 10(9)/L. RESULTS: The neutrophil counts reached a nadir in the fourth week of life and changed slightly from the age of six-months to six-years. The frequency of NP was (from West-to-East): North African Arabs 15.4 %, Green Crescent Arabs 9.8 %, Peninsular Arabs 10.9 %, Iranians 3.1 %, Afghanis 2.5 %, Pakistanis 5.6 %, Indians 10.2 %, and Filipinos 7.3 %. The frequency of severe NP in North African Arabs (Sudanese) was 2.8 %, Green Crescent and Peninsular Arabs ≤1 %, Indians 1.5 %, and Filipinos 1.8 %. In 12,703 Emirati children, the frequency of NP was 10.6 % similar to their adult counterparts. CONCLUSION: The prevalence of childhood NP varied considerably by geoethnicity. Measures to prevent the inappropriate investigations of healthy children with benign neutropenia are proposed. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12878-016-0054-8) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4875641 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-48756412016-05-22 Prevalence of neutropenia in children by nationality Denic, Srdjan Narchi, Hassib Al Mekaini, Lolowa A. Al-Hammadi, Suleiman Al Jabri, Omar N. Souid, Abdul-Kader BMC Hematol Research Article BACKGROUND: A high prevalence of neutropenia has been reported in several ethnic groups amongst whom many healthy individuals with low neutrophil counts undergo unnecessary investigations. This study aims to ascertain the prevalence of neutropenia (NP) in a large cohort of children from North African, Middle Eastern, and Asian countries residing in the United Arab Emirates. METHODS: Neutrophil counts of 26,542 children (one day to six years of age) from 86 countries were analyzed. The subjects were enrolled in the Well-Child-Care program of Ambulatory Health Services of Emirate of Abu Dhabi, United Arab Emirates. NP was defined as a neutrophil count <1.5 × 10(9)/L and severe NP <0.5 × 10(9)/L. RESULTS: The neutrophil counts reached a nadir in the fourth week of life and changed slightly from the age of six-months to six-years. The frequency of NP was (from West-to-East): North African Arabs 15.4 %, Green Crescent Arabs 9.8 %, Peninsular Arabs 10.9 %, Iranians 3.1 %, Afghanis 2.5 %, Pakistanis 5.6 %, Indians 10.2 %, and Filipinos 7.3 %. The frequency of severe NP in North African Arabs (Sudanese) was 2.8 %, Green Crescent and Peninsular Arabs ≤1 %, Indians 1.5 %, and Filipinos 1.8 %. In 12,703 Emirati children, the frequency of NP was 10.6 % similar to their adult counterparts. CONCLUSION: The prevalence of childhood NP varied considerably by geoethnicity. Measures to prevent the inappropriate investigations of healthy children with benign neutropenia are proposed. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12878-016-0054-8) contains supplementary material, which is available to authorized users. BioMed Central 2016-05-21 /pmc/articles/PMC4875641/ /pubmed/27213048 http://dx.doi.org/10.1186/s12878-016-0054-8 Text en © Denic et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Denic, Srdjan Narchi, Hassib Al Mekaini, Lolowa A. Al-Hammadi, Suleiman Al Jabri, Omar N. Souid, Abdul-Kader Prevalence of neutropenia in children by nationality |
title | Prevalence of neutropenia in children by nationality |
title_full | Prevalence of neutropenia in children by nationality |
title_fullStr | Prevalence of neutropenia in children by nationality |
title_full_unstemmed | Prevalence of neutropenia in children by nationality |
title_short | Prevalence of neutropenia in children by nationality |
title_sort | prevalence of neutropenia in children by nationality |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875641/ https://www.ncbi.nlm.nih.gov/pubmed/27213048 http://dx.doi.org/10.1186/s12878-016-0054-8 |
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