Dose Reduction of Caspofungin in Intensive Care Unit Patients with Child Pugh B Will Result in Suboptimal Exposure

BACKGROUND AND OBJECTIVES: Caspofungin is an echinocandin antifungal agent used as first-line therapy for the treatment of invasive candidiasis. The maintenance dose is adapted to body weight (BW) or liver function (Child-Pugh score B or C). We aimed to study the pharmacokinetics of caspofungin and...

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Detalles Bibliográficos
Autores principales: Martial, Lisa C., Brüggemann, Roger J. M., Schouten, Jeroen A., van Leeuwen, Henk J., van Zanten, Arthur R., de Lange, Dylan W., Muilwijk, Eline W., Verweij, Paul E., Burger, David M., Aarnoutse, Rob E., Pickkers, Peter, Dorlo, Thomas P. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875935/
https://www.ncbi.nlm.nih.gov/pubmed/26649870
http://dx.doi.org/10.1007/s40262-015-0347-2

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