Cargando…

LKB1/AMPK inhibits TGF-β1 production and the TGF-β signaling pathway in breast cancer cells

Adenosine monophosphate-activated protein kinase (AMPK) acts as a fuel gauge that maintains energy homeostasis in both normal and cancerous cells, and has emerged as a tumor suppressor. The present study aims to delineate the functional relationship between AMPK and transforming growth factor beta (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Nian-Shuang, Zou, Jun-Rong, Lin, Hui, Ke, Rong, He, Xiao-Ling, Xiao, Lu, Huang, Deqiang, Luo, Lingyu, Lv, Nonghua, Luo, Zhijun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875963/ https://www.ncbi.nlm.nih.gov/pubmed/26718214 http://dx.doi.org/10.1007/s13277-015-4639-9

Ejemplares similares

MLK3 Phophorylates AMPK Independently of LKB1
por: Luo, Lingyu, et al.
Publicado: (2015)

AMPK inhibits Smad3‐mediated autoinduction of TGF‐β1 in gastric cancer cells
por: Zou, Junrong, et al.
Publicado: (2021)

Negative regulation of Bmi-1 by AMPK and implication in cancer progression
por: Huang, Deqiang, et al.
Publicado: (2015)

Negative Regulation of TGFβ Signaling by the Kinase LKB1 and the Scaffolding Protein LIP1
por: Morén, Anita, et al.
Publicado: (2011)

The AMPK Agonist AICAR Inhibits TGF-β1 Induced Activation of Kidney Myofibroblasts
por: Chen, Kuan-Hsing, et al.
Publicado: (2014)

Arsenic Inhibits Neurite Outgrowth by Inhibiting the LKB1–AMPK Signaling Pathway
por: Wang, Xin, et al.
Publicado: (2010)

LKB1 and AMPK differentially regulate pancreatic β-cell identity
por: Kone, Marina, et al.
Publicado: (2014)

LKB1 suppression promotes cardiomyocyte regeneration via LKB1-AMPK-YAP axis
por: Qu, Shuang, et al.
Publicado: (2022)

Breviscapine alleviates NASH by inhibiting TGF‐β‐activated kinase 1‐dependent signaling
por: Lan, Tian, et al.
Publicado: (2021)

Activation of AMPK inhibits TGF-β1-induced airway smooth muscle cells proliferation and its potential mechanisms
por: Pan, Yilin, et al.
Publicado: (2018)

Fortilin interacts with TGF-β1 and prevents TGF-β receptor activation
por: Pinkaew, Decha, et al.
Publicado: (2022)

Vanadium-protein complex inhibits human adipocyte differentiation through the activation of β-catenin and LKB1/AMPK signaling pathway
por: Zhang, Shuang, et al.
Publicado: (2020)

Status of higher TGF-β1 and TGF-β2 levels in the aqueous humour of patients with diabetes and cataracts
por: Gao, Chao, et al.
Publicado: (2022)

Activation of the LKB1-SIK1 signaling pathway inhibits the TGF-β-mediated epithelial-mesenchymal transition and apoptosis resistance of ovarian carcinoma cells
por: Hong, Bo, et al.
Publicado: (2018)

Contextual Regulation of TGF-β Signaling in Liver Cancer
por: Tu, Shuo, et al.
Publicado: (2019)

TGF-β1-Mediated FDNCR1 Regulates Porcine Preadipocyte Differentiation via the TGF-β Signaling Pathway
por: Zhang, Zhe, et al.
Publicado: (2020)

Regorafenib-Attenuated, Bleomycin-Induced Pulmonary Fibrosis by Inhibiting the TGF-β1 Signaling Pathway
por: Li, Xiaohe, et al.
Publicado: (2021)

Mesenchymal stem cells inhibit T cell activation by releasing TGF-β1 from TGF-β1/GARP complex
por: Niu, Jian, et al.
Publicado: (2017)

Role of TGF-β 1 and TGF-β Type II Receptor in Gastric Cancer
por: Park, Dong Il, et al.
Publicado: (2002)

TGF-β1 and TGF-β2 abundance in liver diseases of mice and men
por: Dropmann, Anne, et al.
Publicado: (2016)

EHF promotes colorectal carcinoma progression by activating TGF‐β1 transcription and canonical TGF‐β signaling
por: Wang, Lan, et al.
Publicado: (2020)

Role and clinical significance of TGF-β1 and TGF-βR1 in malignant tumors (Review)
por: Wang, Junmin, et al.
Publicado: (2021)

AMPK potentiation by LKB1 isoforms
por: Thibert, Chantal, et al.
Publicado: (2015)

Polymorphisms of TGF-β1 and TGF-β3 in Chinese women with gestational diabetes mellitus
por: Xu, Yinglei, et al.
Publicado: (2020)

Is Serum TGF-β1 and TGF-β2 levels Correlated to Children with Autism Intensity?
por: YOUSEFI, Jamshid, et al.
Publicado: (2021)

TGF-β1 and TGFβR2 Gene Polymorphisms in Patients with Unstable Angina
por: Malinowski, Damian, et al.
Publicado: (2023)

PKM2 promotes pulmonary fibrosis by stabilizing TGF-β1 receptor I and enhancing TGF-β1 signaling
por: Gao, Shaoyan, et al.
Publicado: (2022)

The Transforming Growth Factor-β1 (TGF-β1) Gene Polymorphisms (TGF-β1 T869C and TGF-β1 T29C) and Susceptibility to Postmenopausal Osteoporosis: A Meta-Analysis
por: Sun, Jiajia, et al.
Publicado: (2015)

BMP1 controls TGFβ1 activation via cleavage of latent TGFβ-binding protein
por: Ge, Gaoxiang, et al.
Publicado: (2006)

Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways
por: Liu, Ning, et al.
Publicado: (2019)

Tangeretin Inhibition of High-Glucose-Induced IL-1β, IL-6, TGF-β1, and VEGF Expression in Human RPE Cells
por: Qin, Dong, et al.
Publicado: (2020)

TGFβ-mediated expression of TGFβ-activating integrins in SSc monocytes: disturbed activation of latent TGFβ?
por: van Caam, A., et al.
Publicado: (2020)

Rejuvenation by inhibiting TGF-β1/pSmad signaling
por: Corder, Elizabeth H., et al.
Publicado: (2015)

TβRIII independently binds type I and type II TGF-β receptors to inhibit TGF-β signaling
por: Tazat, Keren, et al.
Publicado: (2015)

Celastrol inhibits colorectal cancer through TGF-β1/Smad signaling
por: Jiang, Zhitao, et al.
Publicado: (2019)

Quantitation of TGF-β proteins in mouse tissues shows reciprocal changes in TGF-β1 and TGF-β3 in normal vs neoplastic mammary epithelium
por: Flanders, Kathleen C., et al.
Publicado: (2016)

The Expression of BNP, ET-1, and TGF-β1 in Myocardium of Rats with Ventricular Arrhythmias
por: Tian, Meihui, et al.
Publicado: (2019)

TGF-β-activated kinase-1: New insights into the mechanism of TGF-β signaling and kidney disease
por: Kim, Sung Il, et al.
Publicado: (2012)

Absence of integrin-mediated TGFβ1 activation in vivo recapitulates the phenotype of TGFβ1-null mice
por: Yang, Zhiwei, et al.
Publicado: (2007)

TGF-β and TGF-β/Smad Signaling in the Interactions between Echinococcus multilocularis and Its Hosts
por: Wang, Junhua, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_37r8e7uav91eoa4ltcbbkpo4h9