Cargando…

Curcumin and Resveratrol as Promising Natural Remedies with Nanomedicine Approach for the Effective Treatment of Triple Negative Breast Cancer

Researchers have made considerable progress in last few decades in understanding mechanisms underlying pathogenesis of breast cancer, its phenotypes, its molecular and genetic changes, its physiology, and its prognosis. This has allowed us to identify specific targets and design appropriate chemical...

Descripción completa

Detalles Bibliográficos
Autores principales: Shindikar, Amol, Singh, Akshita, Nobre, Malcolm, Kirolikar, Saurabh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875984/
https://www.ncbi.nlm.nih.gov/pubmed/27242900
http://dx.doi.org/10.1155/2016/9750785
_version_ 1782433173096890368
author Shindikar, Amol
Singh, Akshita
Nobre, Malcolm
Kirolikar, Saurabh
author_facet Shindikar, Amol
Singh, Akshita
Nobre, Malcolm
Kirolikar, Saurabh
author_sort Shindikar, Amol
collection PubMed
description Researchers have made considerable progress in last few decades in understanding mechanisms underlying pathogenesis of breast cancer, its phenotypes, its molecular and genetic changes, its physiology, and its prognosis. This has allowed us to identify specific targets and design appropriate chemical entities for effective treatment of most breast cancer phenotypes, resulting in increased patient survivability. Unfortunately, these strategies have been largely ineffective in the treatment of triple negative breast cancer (TNBC). Hormonal receptors lacking render the conventional breast cancer drugs redundant, forcing scientists to identify novel targets for treatment of TNBC. Two natural compounds, curcumin and resveratrol, have been widely reported to have anticancer properties. In vitro and in vivo studies show promising results, though their effectiveness in clinical settings has been less than satisfactory, owing to their feeble pharmacokinetics. Here we discuss these naturally occurring compounds, their mechanism as anticancer agents, their shortcomings in translational research, and possible methodology to improve their pharmacokinetics/pharmacodynamics with advanced drug delivery systems.
format Online
Article
Text
id pubmed-4875984
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-48759842016-05-30 Curcumin and Resveratrol as Promising Natural Remedies with Nanomedicine Approach for the Effective Treatment of Triple Negative Breast Cancer Shindikar, Amol Singh, Akshita Nobre, Malcolm Kirolikar, Saurabh J Oncol Review Article Researchers have made considerable progress in last few decades in understanding mechanisms underlying pathogenesis of breast cancer, its phenotypes, its molecular and genetic changes, its physiology, and its prognosis. This has allowed us to identify specific targets and design appropriate chemical entities for effective treatment of most breast cancer phenotypes, resulting in increased patient survivability. Unfortunately, these strategies have been largely ineffective in the treatment of triple negative breast cancer (TNBC). Hormonal receptors lacking render the conventional breast cancer drugs redundant, forcing scientists to identify novel targets for treatment of TNBC. Two natural compounds, curcumin and resveratrol, have been widely reported to have anticancer properties. In vitro and in vivo studies show promising results, though their effectiveness in clinical settings has been less than satisfactory, owing to their feeble pharmacokinetics. Here we discuss these naturally occurring compounds, their mechanism as anticancer agents, their shortcomings in translational research, and possible methodology to improve their pharmacokinetics/pharmacodynamics with advanced drug delivery systems. Hindawi Publishing Corporation 2016 2016-05-08 /pmc/articles/PMC4875984/ /pubmed/27242900 http://dx.doi.org/10.1155/2016/9750785 Text en Copyright © 2016 Amol Shindikar et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Shindikar, Amol
Singh, Akshita
Nobre, Malcolm
Kirolikar, Saurabh
Curcumin and Resveratrol as Promising Natural Remedies with Nanomedicine Approach for the Effective Treatment of Triple Negative Breast Cancer
title Curcumin and Resveratrol as Promising Natural Remedies with Nanomedicine Approach for the Effective Treatment of Triple Negative Breast Cancer
title_full Curcumin and Resveratrol as Promising Natural Remedies with Nanomedicine Approach for the Effective Treatment of Triple Negative Breast Cancer
title_fullStr Curcumin and Resveratrol as Promising Natural Remedies with Nanomedicine Approach for the Effective Treatment of Triple Negative Breast Cancer
title_full_unstemmed Curcumin and Resveratrol as Promising Natural Remedies with Nanomedicine Approach for the Effective Treatment of Triple Negative Breast Cancer
title_short Curcumin and Resveratrol as Promising Natural Remedies with Nanomedicine Approach for the Effective Treatment of Triple Negative Breast Cancer
title_sort curcumin and resveratrol as promising natural remedies with nanomedicine approach for the effective treatment of triple negative breast cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875984/
https://www.ncbi.nlm.nih.gov/pubmed/27242900
http://dx.doi.org/10.1155/2016/9750785
work_keys_str_mv AT shindikaramol curcuminandresveratrolaspromisingnaturalremedieswithnanomedicineapproachfortheeffectivetreatmentoftriplenegativebreastcancer
AT singhakshita curcuminandresveratrolaspromisingnaturalremedieswithnanomedicineapproachfortheeffectivetreatmentoftriplenegativebreastcancer
AT nobremalcolm curcuminandresveratrolaspromisingnaturalremedieswithnanomedicineapproachfortheeffectivetreatmentoftriplenegativebreastcancer
AT kirolikarsaurabh curcuminandresveratrolaspromisingnaturalremedieswithnanomedicineapproachfortheeffectivetreatmentoftriplenegativebreastcancer