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Studies of human pancreatic elastase treatment of rabbit and human vein rings to predict human therapeutic doses

Vascular tissue contains abundant elastic fibers that contribute to vessel elasticity. Vonapanitase (formerly PRT‐201) is a recombinant human chymotrypsin‐like elastase family member 1 (CELA1) shown to cleave the elastin component of elastic fibers, resulting in increased vessel diameter. The purpos...

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Detalles Bibliográficos
Autores principales:	Burke, Steven K., Bunton, David, Bingham, Karen, Moss, Emma, Bland, Kimberly S., Starcher, Barry, Wong, Marco D., Franano, F. Nicholas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876140/ https://www.ncbi.nlm.nih.gov/pubmed/27433340 http://dx.doi.org/10.1002/prp2.229

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