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Anti‐inflammatory, antiapoptotic, and antioxidant activity of fluoxetine

Fluoxetine is a selective serotonin uptake inhibitor that has been widely used to determine the neurotransmission of serotonin in the central nervous system. This substance has emerged as the drug of choice for the treatment of depression due to is safer profile, fewer side effects, and greater tole...

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Autores principales: Caiaffo, Vitor, Oliveira, Belisa D. R., de Sá, Fabrício B., Evêncio Neto, Joaquim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876141/
https://www.ncbi.nlm.nih.gov/pubmed/27433341
http://dx.doi.org/10.1002/prp2.231
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author Caiaffo, Vitor
Oliveira, Belisa D. R.
de Sá, Fabrício B.
Evêncio Neto, Joaquim
author_facet Caiaffo, Vitor
Oliveira, Belisa D. R.
de Sá, Fabrício B.
Evêncio Neto, Joaquim
author_sort Caiaffo, Vitor
collection PubMed
description Fluoxetine is a selective serotonin uptake inhibitor that has been widely used to determine the neurotransmission of serotonin in the central nervous system. This substance has emerged as the drug of choice for the treatment of depression due to is safer profile, fewer side effects, and greater tolerability. Studies have found the following important functions of fluoxetine related to the central nervous system: neuroprotection; anti‐inflammatory properties similar to standard drugs for the treatment of inflammatory conditions; antioxidant properties, contributing to its therapeutic action and an important intracellular mechanism underlying the protective pharmacological effects seen in clinical practice in the treatment of different stress‐related adverse health conditions; and antiapoptotic properties, with greater neuron survival and a reduction in apoptosis mediators as well as oxidative substances, such as superoxide dismutase and hydrogen peroxide. The aim of this study was to perform a review of the literature on the important role of fluoxetine in anti‐inflammatory, cell survival, and neuron trophicity mechanisms (antiapoptotic properties) as well as its role regarding enzymes of the antioxidant defense system.
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spelling pubmed-48761412016-07-18 Anti‐inflammatory, antiapoptotic, and antioxidant activity of fluoxetine Caiaffo, Vitor Oliveira, Belisa D. R. de Sá, Fabrício B. Evêncio Neto, Joaquim Pharmacol Res Perspect Invited Reviews Fluoxetine is a selective serotonin uptake inhibitor that has been widely used to determine the neurotransmission of serotonin in the central nervous system. This substance has emerged as the drug of choice for the treatment of depression due to is safer profile, fewer side effects, and greater tolerability. Studies have found the following important functions of fluoxetine related to the central nervous system: neuroprotection; anti‐inflammatory properties similar to standard drugs for the treatment of inflammatory conditions; antioxidant properties, contributing to its therapeutic action and an important intracellular mechanism underlying the protective pharmacological effects seen in clinical practice in the treatment of different stress‐related adverse health conditions; and antiapoptotic properties, with greater neuron survival and a reduction in apoptosis mediators as well as oxidative substances, such as superoxide dismutase and hydrogen peroxide. The aim of this study was to perform a review of the literature on the important role of fluoxetine in anti‐inflammatory, cell survival, and neuron trophicity mechanisms (antiapoptotic properties) as well as its role regarding enzymes of the antioxidant defense system. John Wiley and Sons Inc. 2016-04-07 /pmc/articles/PMC4876141/ /pubmed/27433341 http://dx.doi.org/10.1002/prp2.231 Text en © 2016 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Reviews
Caiaffo, Vitor
Oliveira, Belisa D. R.
de Sá, Fabrício B.
Evêncio Neto, Joaquim
Anti‐inflammatory, antiapoptotic, and antioxidant activity of fluoxetine
title Anti‐inflammatory, antiapoptotic, and antioxidant activity of fluoxetine
title_full Anti‐inflammatory, antiapoptotic, and antioxidant activity of fluoxetine
title_fullStr Anti‐inflammatory, antiapoptotic, and antioxidant activity of fluoxetine
title_full_unstemmed Anti‐inflammatory, antiapoptotic, and antioxidant activity of fluoxetine
title_short Anti‐inflammatory, antiapoptotic, and antioxidant activity of fluoxetine
title_sort anti‐inflammatory, antiapoptotic, and antioxidant activity of fluoxetine
topic Invited Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876141/
https://www.ncbi.nlm.nih.gov/pubmed/27433341
http://dx.doi.org/10.1002/prp2.231
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