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Anti‐inflammatory, antiapoptotic, and antioxidant activity of fluoxetine
Fluoxetine is a selective serotonin uptake inhibitor that has been widely used to determine the neurotransmission of serotonin in the central nervous system. This substance has emerged as the drug of choice for the treatment of depression due to is safer profile, fewer side effects, and greater tole...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876141/ https://www.ncbi.nlm.nih.gov/pubmed/27433341 http://dx.doi.org/10.1002/prp2.231 |
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author | Caiaffo, Vitor Oliveira, Belisa D. R. de Sá, Fabrício B. Evêncio Neto, Joaquim |
author_facet | Caiaffo, Vitor Oliveira, Belisa D. R. de Sá, Fabrício B. Evêncio Neto, Joaquim |
author_sort | Caiaffo, Vitor |
collection | PubMed |
description | Fluoxetine is a selective serotonin uptake inhibitor that has been widely used to determine the neurotransmission of serotonin in the central nervous system. This substance has emerged as the drug of choice for the treatment of depression due to is safer profile, fewer side effects, and greater tolerability. Studies have found the following important functions of fluoxetine related to the central nervous system: neuroprotection; anti‐inflammatory properties similar to standard drugs for the treatment of inflammatory conditions; antioxidant properties, contributing to its therapeutic action and an important intracellular mechanism underlying the protective pharmacological effects seen in clinical practice in the treatment of different stress‐related adverse health conditions; and antiapoptotic properties, with greater neuron survival and a reduction in apoptosis mediators as well as oxidative substances, such as superoxide dismutase and hydrogen peroxide. The aim of this study was to perform a review of the literature on the important role of fluoxetine in anti‐inflammatory, cell survival, and neuron trophicity mechanisms (antiapoptotic properties) as well as its role regarding enzymes of the antioxidant defense system. |
format | Online Article Text |
id | pubmed-4876141 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-48761412016-07-18 Anti‐inflammatory, antiapoptotic, and antioxidant activity of fluoxetine Caiaffo, Vitor Oliveira, Belisa D. R. de Sá, Fabrício B. Evêncio Neto, Joaquim Pharmacol Res Perspect Invited Reviews Fluoxetine is a selective serotonin uptake inhibitor that has been widely used to determine the neurotransmission of serotonin in the central nervous system. This substance has emerged as the drug of choice for the treatment of depression due to is safer profile, fewer side effects, and greater tolerability. Studies have found the following important functions of fluoxetine related to the central nervous system: neuroprotection; anti‐inflammatory properties similar to standard drugs for the treatment of inflammatory conditions; antioxidant properties, contributing to its therapeutic action and an important intracellular mechanism underlying the protective pharmacological effects seen in clinical practice in the treatment of different stress‐related adverse health conditions; and antiapoptotic properties, with greater neuron survival and a reduction in apoptosis mediators as well as oxidative substances, such as superoxide dismutase and hydrogen peroxide. The aim of this study was to perform a review of the literature on the important role of fluoxetine in anti‐inflammatory, cell survival, and neuron trophicity mechanisms (antiapoptotic properties) as well as its role regarding enzymes of the antioxidant defense system. John Wiley and Sons Inc. 2016-04-07 /pmc/articles/PMC4876141/ /pubmed/27433341 http://dx.doi.org/10.1002/prp2.231 Text en © 2016 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Reviews Caiaffo, Vitor Oliveira, Belisa D. R. de Sá, Fabrício B. Evêncio Neto, Joaquim Anti‐inflammatory, antiapoptotic, and antioxidant activity of fluoxetine |
title | Anti‐inflammatory, antiapoptotic, and antioxidant activity of fluoxetine |
title_full | Anti‐inflammatory, antiapoptotic, and antioxidant activity of fluoxetine |
title_fullStr | Anti‐inflammatory, antiapoptotic, and antioxidant activity of fluoxetine |
title_full_unstemmed | Anti‐inflammatory, antiapoptotic, and antioxidant activity of fluoxetine |
title_short | Anti‐inflammatory, antiapoptotic, and antioxidant activity of fluoxetine |
title_sort | anti‐inflammatory, antiapoptotic, and antioxidant activity of fluoxetine |
topic | Invited Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876141/ https://www.ncbi.nlm.nih.gov/pubmed/27433341 http://dx.doi.org/10.1002/prp2.231 |
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