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Primary Intracranial Synovial Sarcoma
Background. Synovial sarcoma is an aggressive soft tissue sarcoma with uncertain histological origin. The pathology frequently presents as a localized disease, especially near large joints around the knee and thigh. Intracranial disease, which is rare, has been reported as metastasis from synovial s...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876212/ https://www.ncbi.nlm.nih.gov/pubmed/27247811 http://dx.doi.org/10.1155/2016/5608315 |
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author | Patel, Mohit Li, Luyuan Nguyen, Ha Son Doan, Ninh Sinson, Grant Mueller, Wade |
author_facet | Patel, Mohit Li, Luyuan Nguyen, Ha Son Doan, Ninh Sinson, Grant Mueller, Wade |
author_sort | Patel, Mohit |
collection | PubMed |
description | Background. Synovial sarcoma is an aggressive soft tissue sarcoma with uncertain histological origin. The pathology frequently presents as a localized disease, especially near large joints around the knee and thigh. Intracranial disease, which is rare, has been reported as metastasis from synovial sarcoma. We report a case with no obvious primary extracranial pathology, suggesting primary intracranial disease; this has not been reported in the literature. Case Description. A 21-year-old male, with a prior right skull lesion resection for atypical spindle cell neoplasm, presented with headaches, gait instability, left arm weakness, and left homonymous hemianopsia. CT of head demonstrated a right parietal hemorrhagic lesion with mass effect, requiring surgical decompression. Histopathology revealed synovial sarcoma. FISH analysis noted the existence of the t(X;18)(p11.2;q11.2) chromosomal translocation. PET scan did not show other metastatic disease. He underwent stereotactic radiotherapy and adjuvant chemotherapy. At 2-year follow-up, he remained nonfocal without recurrence. Conclusion. We report the first known case of primary intracranial synovial sarcoma. Moreover, we stress that intracranial lesions may have a tendency for hemorrhage, requiring urgent lifesaving decompression. |
format | Online Article Text |
id | pubmed-4876212 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-48762122016-05-31 Primary Intracranial Synovial Sarcoma Patel, Mohit Li, Luyuan Nguyen, Ha Son Doan, Ninh Sinson, Grant Mueller, Wade Case Rep Neurol Med Case Report Background. Synovial sarcoma is an aggressive soft tissue sarcoma with uncertain histological origin. The pathology frequently presents as a localized disease, especially near large joints around the knee and thigh. Intracranial disease, which is rare, has been reported as metastasis from synovial sarcoma. We report a case with no obvious primary extracranial pathology, suggesting primary intracranial disease; this has not been reported in the literature. Case Description. A 21-year-old male, with a prior right skull lesion resection for atypical spindle cell neoplasm, presented with headaches, gait instability, left arm weakness, and left homonymous hemianopsia. CT of head demonstrated a right parietal hemorrhagic lesion with mass effect, requiring surgical decompression. Histopathology revealed synovial sarcoma. FISH analysis noted the existence of the t(X;18)(p11.2;q11.2) chromosomal translocation. PET scan did not show other metastatic disease. He underwent stereotactic radiotherapy and adjuvant chemotherapy. At 2-year follow-up, he remained nonfocal without recurrence. Conclusion. We report the first known case of primary intracranial synovial sarcoma. Moreover, we stress that intracranial lesions may have a tendency for hemorrhage, requiring urgent lifesaving decompression. Hindawi Publishing Corporation 2016 2016-05-09 /pmc/articles/PMC4876212/ /pubmed/27247811 http://dx.doi.org/10.1155/2016/5608315 Text en Copyright © 2016 Mohit Patel et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Patel, Mohit Li, Luyuan Nguyen, Ha Son Doan, Ninh Sinson, Grant Mueller, Wade Primary Intracranial Synovial Sarcoma |
title | Primary Intracranial Synovial Sarcoma |
title_full | Primary Intracranial Synovial Sarcoma |
title_fullStr | Primary Intracranial Synovial Sarcoma |
title_full_unstemmed | Primary Intracranial Synovial Sarcoma |
title_short | Primary Intracranial Synovial Sarcoma |
title_sort | primary intracranial synovial sarcoma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876212/ https://www.ncbi.nlm.nih.gov/pubmed/27247811 http://dx.doi.org/10.1155/2016/5608315 |
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