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Development and Evaluation of Stability of a Gel Formulation Containing the Monoterpene Borneol

Borneol is a bicyclic monoterpenoid alcohol commonly used in traditional Chinese and Indian medicine. It is extracted from the essential oil of various medicinal plants. It has antibacterial, analgesic, and anti-inflammatory action proven in studies that used oral and intraperitoneal applications of...

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Autores principales: Dantas, Milla Gabriela Belarmino, Reis, Silvio Alan Gonçalves Bomfim, Damasceno, Camila Mahara Dias, Rolim, Larissa Araújo, Rolim-Neto, Pedro José, Carvalho, Ferdinando Oliveira, Quintans-Junior, Lucindo José, Almeida, Jackson Roberto Guedes da Silva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876256/
https://www.ncbi.nlm.nih.gov/pubmed/27247965
http://dx.doi.org/10.1155/2016/7394685
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author Dantas, Milla Gabriela Belarmino
Reis, Silvio Alan Gonçalves Bomfim
Damasceno, Camila Mahara Dias
Rolim, Larissa Araújo
Rolim-Neto, Pedro José
Carvalho, Ferdinando Oliveira
Quintans-Junior, Lucindo José
Almeida, Jackson Roberto Guedes da Silva
author_facet Dantas, Milla Gabriela Belarmino
Reis, Silvio Alan Gonçalves Bomfim
Damasceno, Camila Mahara Dias
Rolim, Larissa Araújo
Rolim-Neto, Pedro José
Carvalho, Ferdinando Oliveira
Quintans-Junior, Lucindo José
Almeida, Jackson Roberto Guedes da Silva
author_sort Dantas, Milla Gabriela Belarmino
collection PubMed
description Borneol is a bicyclic monoterpenoid alcohol commonly used in traditional Chinese and Indian medicine. It is extracted from the essential oil of various medicinal plants. It has antibacterial, analgesic, and anti-inflammatory action proven in studies that used oral and intraperitoneal applications of this monoterpene in mice. The current study was designed to develop a topical gel formulation containing the monoterpene borneol using carbopol as gel base and to evaluate its stability. The prepared formulation was subjected to physical characterization and physical-chemistry assessment. The gel was prepared from carbopol and 5% of borneol. The prepared gel was subjected to pharmacotechnical tests such as its pH, viscosity, conductivity, spreadability, centrifugation, and accelerated stability with freezing-thaw cycle. The borneol was successfully incorporated into the carbopol formulation. Borneol gel (BG5) showed good stability after eight months of its development and after 12 days in the freeze-thaw cycle, not showing statistical difference in pH value, conductivity, and viscosity before and after test. Furthermore, the formulation showed a good spreadability. Therefore, it was concluded that the formulation could be very promising alternative for the topical or transdermal treatment of skin diseases.
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spelling pubmed-48762562016-05-31 Development and Evaluation of Stability of a Gel Formulation Containing the Monoterpene Borneol Dantas, Milla Gabriela Belarmino Reis, Silvio Alan Gonçalves Bomfim Damasceno, Camila Mahara Dias Rolim, Larissa Araújo Rolim-Neto, Pedro José Carvalho, Ferdinando Oliveira Quintans-Junior, Lucindo José Almeida, Jackson Roberto Guedes da Silva ScientificWorldJournal Research Article Borneol is a bicyclic monoterpenoid alcohol commonly used in traditional Chinese and Indian medicine. It is extracted from the essential oil of various medicinal plants. It has antibacterial, analgesic, and anti-inflammatory action proven in studies that used oral and intraperitoneal applications of this monoterpene in mice. The current study was designed to develop a topical gel formulation containing the monoterpene borneol using carbopol as gel base and to evaluate its stability. The prepared formulation was subjected to physical characterization and physical-chemistry assessment. The gel was prepared from carbopol and 5% of borneol. The prepared gel was subjected to pharmacotechnical tests such as its pH, viscosity, conductivity, spreadability, centrifugation, and accelerated stability with freezing-thaw cycle. The borneol was successfully incorporated into the carbopol formulation. Borneol gel (BG5) showed good stability after eight months of its development and after 12 days in the freeze-thaw cycle, not showing statistical difference in pH value, conductivity, and viscosity before and after test. Furthermore, the formulation showed a good spreadability. Therefore, it was concluded that the formulation could be very promising alternative for the topical or transdermal treatment of skin diseases. Hindawi Publishing Corporation 2016 2016-05-09 /pmc/articles/PMC4876256/ /pubmed/27247965 http://dx.doi.org/10.1155/2016/7394685 Text en Copyright © 2016 Milla Gabriela Belarmino Dantas et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dantas, Milla Gabriela Belarmino
Reis, Silvio Alan Gonçalves Bomfim
Damasceno, Camila Mahara Dias
Rolim, Larissa Araújo
Rolim-Neto, Pedro José
Carvalho, Ferdinando Oliveira
Quintans-Junior, Lucindo José
Almeida, Jackson Roberto Guedes da Silva
Development and Evaluation of Stability of a Gel Formulation Containing the Monoterpene Borneol
title Development and Evaluation of Stability of a Gel Formulation Containing the Monoterpene Borneol
title_full Development and Evaluation of Stability of a Gel Formulation Containing the Monoterpene Borneol
title_fullStr Development and Evaluation of Stability of a Gel Formulation Containing the Monoterpene Borneol
title_full_unstemmed Development and Evaluation of Stability of a Gel Formulation Containing the Monoterpene Borneol
title_short Development and Evaluation of Stability of a Gel Formulation Containing the Monoterpene Borneol
title_sort development and evaluation of stability of a gel formulation containing the monoterpene borneol
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876256/
https://www.ncbi.nlm.nih.gov/pubmed/27247965
http://dx.doi.org/10.1155/2016/7394685
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