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α-Synuclein induced toxicity in brain stem serotonin neurons mediated by an AAV vector driven by the tryptophan hydroxylase promoter

We studied the impact of α-synuclein overexpression in brainstem serotonin neurons using a novel vector construct where the expression of human wildtype α-synuclein is driven by the tryptophan hydroxylase promoter, allowing expression of α-synuclein at elevated levels, and with high selectivity, in...

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Detalles Bibliográficos
Autores principales:	Wan, Oi Wan, Shin, Eunju, Mattsson, Bengt, Caudal, Dorian, Svenningsson, Per, Björklund, Anders
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876322/ https://www.ncbi.nlm.nih.gov/pubmed/27211987 http://dx.doi.org/10.1038/srep26285

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