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COPD and stroke: are systemic inflammation and oxidative stress the missing links?
Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and loss of lung function, and is currently the third largest cause of death in the world. It is now well established that cardiovascular-related comorbidities such as stroke contribute to morbidity and m...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876483/ https://www.ncbi.nlm.nih.gov/pubmed/27215677 http://dx.doi.org/10.1042/CS20160043 |
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author | Austin, Victoria Crack, Peter J. Bozinovski, Steven Miller, Alyson A. Vlahos, Ross |
author_facet | Austin, Victoria Crack, Peter J. Bozinovski, Steven Miller, Alyson A. Vlahos, Ross |
author_sort | Austin, Victoria |
collection | PubMed |
description | Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and loss of lung function, and is currently the third largest cause of death in the world. It is now well established that cardiovascular-related comorbidities such as stroke contribute to morbidity and mortality in COPD. The mechanisms linking COPD and stroke remain to be fully defined but are likely to be interconnected. The association between COPD and stroke may be largely dependent on shared risk factors such as aging and smoking, or the association of COPD with traditional stroke risk factors. In addition, we propose that COPD-related systemic inflammation and oxidative stress may play important roles by promoting cerebral vascular dysfunction and platelet hyperactivity. In this review, we briefly discuss the pathogenesis of COPD, acute exacerbations of COPD (AECOPD) and cardiovascular comorbidities associated with COPD, in particular stroke. We also highlight and discuss the potential mechanisms underpinning the link between COPD and stroke, with a particular focus on the roles of systemic inflammation and oxidative stress. |
format | Online Article Text |
id | pubmed-4876483 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-48764832016-06-02 COPD and stroke: are systemic inflammation and oxidative stress the missing links? Austin, Victoria Crack, Peter J. Bozinovski, Steven Miller, Alyson A. Vlahos, Ross Clin Sci (Lond) Review Articles Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and loss of lung function, and is currently the third largest cause of death in the world. It is now well established that cardiovascular-related comorbidities such as stroke contribute to morbidity and mortality in COPD. The mechanisms linking COPD and stroke remain to be fully defined but are likely to be interconnected. The association between COPD and stroke may be largely dependent on shared risk factors such as aging and smoking, or the association of COPD with traditional stroke risk factors. In addition, we propose that COPD-related systemic inflammation and oxidative stress may play important roles by promoting cerebral vascular dysfunction and platelet hyperactivity. In this review, we briefly discuss the pathogenesis of COPD, acute exacerbations of COPD (AECOPD) and cardiovascular comorbidities associated with COPD, in particular stroke. We also highlight and discuss the potential mechanisms underpinning the link between COPD and stroke, with a particular focus on the roles of systemic inflammation and oxidative stress. Portland Press Ltd. 2016-05-23 2016-07-01 /pmc/articles/PMC4876483/ /pubmed/27215677 http://dx.doi.org/10.1042/CS20160043 Text en © 2016 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Review Articles Austin, Victoria Crack, Peter J. Bozinovski, Steven Miller, Alyson A. Vlahos, Ross COPD and stroke: are systemic inflammation and oxidative stress the missing links? |
title | COPD and stroke: are systemic inflammation and oxidative stress the missing links? |
title_full | COPD and stroke: are systemic inflammation and oxidative stress the missing links? |
title_fullStr | COPD and stroke: are systemic inflammation and oxidative stress the missing links? |
title_full_unstemmed | COPD and stroke: are systemic inflammation and oxidative stress the missing links? |
title_short | COPD and stroke: are systemic inflammation and oxidative stress the missing links? |
title_sort | copd and stroke: are systemic inflammation and oxidative stress the missing links? |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876483/ https://www.ncbi.nlm.nih.gov/pubmed/27215677 http://dx.doi.org/10.1042/CS20160043 |
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