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Current Therapy of Drugs in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS), commonly termed as motor neuron disease (MND) in UK, is a chronically lethal disorder among the neurodegenerative diseases, meanwhile. ALS is basically irreversible and progressive deterioration of upper and lower motor neurons in the motor cortex, brain stem and...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Bentham Science Publishers
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876587/ https://www.ncbi.nlm.nih.gov/pubmed/26786249 http://dx.doi.org/10.2174/1570159X14666160120152423 |
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author | Lu, Haiyan Le, Wei Dong Xie, Ya-Ying Wang, Xiao-Ping |
author_facet | Lu, Haiyan Le, Wei Dong Xie, Ya-Ying Wang, Xiao-Ping |
author_sort | Lu, Haiyan |
collection | PubMed |
description | Amyotrophic lateral sclerosis (ALS), commonly termed as motor neuron disease (MND) in UK, is a chronically lethal disorder among the neurodegenerative diseases, meanwhile. ALS is basically irreversible and progressive deterioration of upper and lower motor neurons in the motor cortex, brain stem and medulla spinalis. Riluzole, used for the treatment of ALS, was demonstrated to slightly delay the initiation of respiratory dysfunction and extend the median survival of patients by a few months. In this study, the key biochemical defects were discussed, such as: mutant Cu/Zn superoxide dismutase, mitochondrial protectants, and anti-excitotoxic/ anti-oxidative / anti-inflammatory/ anti-apoptotic agents, so the related drug candidates that have been studied in ALS models would possibly be further used in ALS patients. |
format | Online Article Text |
id | pubmed-4876587 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-48765872016-11-01 Current Therapy of Drugs in Amyotrophic Lateral Sclerosis Lu, Haiyan Le, Wei Dong Xie, Ya-Ying Wang, Xiao-Ping Curr Neuropharmacol Article Amyotrophic lateral sclerosis (ALS), commonly termed as motor neuron disease (MND) in UK, is a chronically lethal disorder among the neurodegenerative diseases, meanwhile. ALS is basically irreversible and progressive deterioration of upper and lower motor neurons in the motor cortex, brain stem and medulla spinalis. Riluzole, used for the treatment of ALS, was demonstrated to slightly delay the initiation of respiratory dysfunction and extend the median survival of patients by a few months. In this study, the key biochemical defects were discussed, such as: mutant Cu/Zn superoxide dismutase, mitochondrial protectants, and anti-excitotoxic/ anti-oxidative / anti-inflammatory/ anti-apoptotic agents, so the related drug candidates that have been studied in ALS models would possibly be further used in ALS patients. Bentham Science Publishers 2016-05 2016-05 /pmc/articles/PMC4876587/ /pubmed/26786249 http://dx.doi.org/10.2174/1570159X14666160120152423 Text en ©2016 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Lu, Haiyan Le, Wei Dong Xie, Ya-Ying Wang, Xiao-Ping Current Therapy of Drugs in Amyotrophic Lateral Sclerosis |
title | Current Therapy of Drugs in Amyotrophic Lateral Sclerosis |
title_full | Current Therapy of Drugs in Amyotrophic Lateral Sclerosis |
title_fullStr | Current Therapy of Drugs in Amyotrophic Lateral Sclerosis |
title_full_unstemmed | Current Therapy of Drugs in Amyotrophic Lateral Sclerosis |
title_short | Current Therapy of Drugs in Amyotrophic Lateral Sclerosis |
title_sort | current therapy of drugs in amyotrophic lateral sclerosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876587/ https://www.ncbi.nlm.nih.gov/pubmed/26786249 http://dx.doi.org/10.2174/1570159X14666160120152423 |
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