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Current Treatment Options for Alzheimer's Disease and Parkinson's Disease Dementia
Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common neurodegenerative disorders encountered in clinical practice. Whilst dementia has long been synonymous with AD, it is becoming more widely accepted as part of the clinical spectrum in PD (PDD). Neuropsychiatric c...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876589/ https://www.ncbi.nlm.nih.gov/pubmed/26644155 http://dx.doi.org/10.2174/1570159X14666151208112754 |
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author | Szeto, Jennifer Y.Y. Lewis, Simon J.G. |
author_facet | Szeto, Jennifer Y.Y. Lewis, Simon J.G. |
author_sort | Szeto, Jennifer Y.Y. |
collection | PubMed |
description | Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common neurodegenerative disorders encountered in clinical practice. Whilst dementia has long been synonymous with AD, it is becoming more widely accepted as part of the clinical spectrum in PD (PDD). Neuropsychiatric complications, including psychosis, mood and anxiety disorders, and sleep disorders also frequently co-exist with cognitive dysfunctions in AD and PDD patients. The incidence of such symptoms is often a significant source of disability, and may aggravate pre-existing cognitive deficits. Management of AD and PDD involves both pharmacological and non-pharmacological measures. Although research on pharmacological therapies for AD and PDD has so far had some success in terms of developing symptomatic treatments, the benefits are often marginal and non-sustained. These shortcomings have led to the investigation of non-pharmacological and novel treatments for both AD and PD. Furthermore, in light of the diverse constellation of other neuropsychiatric, physical, and behavioural symptoms that often occur in AD and PD, consideration needs to be given to the potential side effects of pharmacological treatments where improving one symptom may lead to the worsening of another, rendering the clinical management of these patients challenging. Therefore, the present article will critically review the evidence for both pharmacological and non-pharmacological treatments for cognitive impairment in AD and PD patients. Treatment options for other concomitant neuropsychiatric and behavioural symptoms, as well as novel treatment strategies will also be discussed. |
format | Online Article Text |
id | pubmed-4876589 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-48765892016-11-01 Current Treatment Options for Alzheimer's Disease and Parkinson's Disease Dementia Szeto, Jennifer Y.Y. Lewis, Simon J.G. Curr Neuropharmacol Article Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common neurodegenerative disorders encountered in clinical practice. Whilst dementia has long been synonymous with AD, it is becoming more widely accepted as part of the clinical spectrum in PD (PDD). Neuropsychiatric complications, including psychosis, mood and anxiety disorders, and sleep disorders also frequently co-exist with cognitive dysfunctions in AD and PDD patients. The incidence of such symptoms is often a significant source of disability, and may aggravate pre-existing cognitive deficits. Management of AD and PDD involves both pharmacological and non-pharmacological measures. Although research on pharmacological therapies for AD and PDD has so far had some success in terms of developing symptomatic treatments, the benefits are often marginal and non-sustained. These shortcomings have led to the investigation of non-pharmacological and novel treatments for both AD and PD. Furthermore, in light of the diverse constellation of other neuropsychiatric, physical, and behavioural symptoms that often occur in AD and PD, consideration needs to be given to the potential side effects of pharmacological treatments where improving one symptom may lead to the worsening of another, rendering the clinical management of these patients challenging. Therefore, the present article will critically review the evidence for both pharmacological and non-pharmacological treatments for cognitive impairment in AD and PD patients. Treatment options for other concomitant neuropsychiatric and behavioural symptoms, as well as novel treatment strategies will also be discussed. Bentham Science Publishers 2016-05 2016-05 /pmc/articles/PMC4876589/ /pubmed/26644155 http://dx.doi.org/10.2174/1570159X14666151208112754 Text en © 2016 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Szeto, Jennifer Y.Y. Lewis, Simon J.G. Current Treatment Options for Alzheimer's Disease and Parkinson's Disease Dementia |
title | Current Treatment Options for Alzheimer's Disease and Parkinson's Disease Dementia |
title_full | Current Treatment Options for Alzheimer's Disease and Parkinson's Disease Dementia |
title_fullStr | Current Treatment Options for Alzheimer's Disease and Parkinson's Disease Dementia |
title_full_unstemmed | Current Treatment Options for Alzheimer's Disease and Parkinson's Disease Dementia |
title_short | Current Treatment Options for Alzheimer's Disease and Parkinson's Disease Dementia |
title_sort | current treatment options for alzheimer's disease and parkinson's disease dementia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876589/ https://www.ncbi.nlm.nih.gov/pubmed/26644155 http://dx.doi.org/10.2174/1570159X14666151208112754 |
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