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From Binding-Induced Dynamic Effects in SH3 Structures to Evolutionary Conserved Sectors
Src Homology 3 domains are ubiquitous small interaction modules known to act as docking sites and regulatory elements in a wide range of proteins. Prior experimental NMR work on the SH3 domain of Src showed that ligand binding induces long-range dynamic changes consistent with an induced fit mechani...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877006/ https://www.ncbi.nlm.nih.gov/pubmed/27213566 http://dx.doi.org/10.1371/journal.pcbi.1004938 |