Cargando…
Perfusion Deficits and Functional Connectivity Alterations in Memory-Related Regions of Patients with Post-Traumatic Stress Disorder
To explore the potential alterations in cerebral blood flow (CBF) and functional connectivity of recent onset post-traumatic stress disorder (PTSD) induced by a single prolonged trauma exposure, we recruited 20 survivors experiencing the same coal mining flood disaster as the PTSD (n = 10) and non-P...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877105/ https://www.ncbi.nlm.nih.gov/pubmed/27213610 http://dx.doi.org/10.1371/journal.pone.0156016 |
_version_ | 1782433332730003456 |
---|---|
author | Liu, Yang Li, Baojuan Feng, Na Pu, Huangsheng Zhang, Xi Lu, Hongbing Yin, Hong |
author_facet | Liu, Yang Li, Baojuan Feng, Na Pu, Huangsheng Zhang, Xi Lu, Hongbing Yin, Hong |
author_sort | Liu, Yang |
collection | PubMed |
description | To explore the potential alterations in cerebral blood flow (CBF) and functional connectivity of recent onset post-traumatic stress disorder (PTSD) induced by a single prolonged trauma exposure, we recruited 20 survivors experiencing the same coal mining flood disaster as the PTSD (n = 10) and non-PTSD (n = 10) group, respectively. The pulsed arterial spin labeling (ASL) images were acquired with a 3.0T MRI scanner and the partial volume (PV) effect in the images was corrected for better CBF estimation. Alterations in CBF were analyzed using both uncorrected and PV-corrected CBF maps. By using altered CBF regions as regions-of-interest, seed-based functional connectivity analysis was then performed. While only one CBF deficit in right corpus callosum of PTSD patients was detected using uncorrected CBF, three more regions (bilateral frontal lobes and right superior frontal gyrus) were identified using PV-corrected CBF. Furthermore, the regional CBF of right superior frontal gyrus exhibited significantly negative correlation with the symptom severity (r = −0.759, p = 0.018). The resting-state functional connectivity analysis revealed increased connectivity between left frontal lobe and right parietal lobe. The results indicated the symptom-specific perfusion deficits and an aberrant connectivity in memory-related regions of PTSD patients when using PV-corrected ASL data. It also suggested that PV-corrected CBF exhibits more subtle changes that may be beneficial to perfusion and connectivity analysis. |
format | Online Article Text |
id | pubmed-4877105 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-48771052016-06-09 Perfusion Deficits and Functional Connectivity Alterations in Memory-Related Regions of Patients with Post-Traumatic Stress Disorder Liu, Yang Li, Baojuan Feng, Na Pu, Huangsheng Zhang, Xi Lu, Hongbing Yin, Hong PLoS One Research Article To explore the potential alterations in cerebral blood flow (CBF) and functional connectivity of recent onset post-traumatic stress disorder (PTSD) induced by a single prolonged trauma exposure, we recruited 20 survivors experiencing the same coal mining flood disaster as the PTSD (n = 10) and non-PTSD (n = 10) group, respectively. The pulsed arterial spin labeling (ASL) images were acquired with a 3.0T MRI scanner and the partial volume (PV) effect in the images was corrected for better CBF estimation. Alterations in CBF were analyzed using both uncorrected and PV-corrected CBF maps. By using altered CBF regions as regions-of-interest, seed-based functional connectivity analysis was then performed. While only one CBF deficit in right corpus callosum of PTSD patients was detected using uncorrected CBF, three more regions (bilateral frontal lobes and right superior frontal gyrus) were identified using PV-corrected CBF. Furthermore, the regional CBF of right superior frontal gyrus exhibited significantly negative correlation with the symptom severity (r = −0.759, p = 0.018). The resting-state functional connectivity analysis revealed increased connectivity between left frontal lobe and right parietal lobe. The results indicated the symptom-specific perfusion deficits and an aberrant connectivity in memory-related regions of PTSD patients when using PV-corrected ASL data. It also suggested that PV-corrected CBF exhibits more subtle changes that may be beneficial to perfusion and connectivity analysis. Public Library of Science 2016-05-23 /pmc/articles/PMC4877105/ /pubmed/27213610 http://dx.doi.org/10.1371/journal.pone.0156016 Text en © 2016 Liu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Liu, Yang Li, Baojuan Feng, Na Pu, Huangsheng Zhang, Xi Lu, Hongbing Yin, Hong Perfusion Deficits and Functional Connectivity Alterations in Memory-Related Regions of Patients with Post-Traumatic Stress Disorder |
title | Perfusion Deficits and Functional Connectivity Alterations in Memory-Related Regions of Patients with Post-Traumatic Stress Disorder |
title_full | Perfusion Deficits and Functional Connectivity Alterations in Memory-Related Regions of Patients with Post-Traumatic Stress Disorder |
title_fullStr | Perfusion Deficits and Functional Connectivity Alterations in Memory-Related Regions of Patients with Post-Traumatic Stress Disorder |
title_full_unstemmed | Perfusion Deficits and Functional Connectivity Alterations in Memory-Related Regions of Patients with Post-Traumatic Stress Disorder |
title_short | Perfusion Deficits and Functional Connectivity Alterations in Memory-Related Regions of Patients with Post-Traumatic Stress Disorder |
title_sort | perfusion deficits and functional connectivity alterations in memory-related regions of patients with post-traumatic stress disorder |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877105/ https://www.ncbi.nlm.nih.gov/pubmed/27213610 http://dx.doi.org/10.1371/journal.pone.0156016 |
work_keys_str_mv | AT liuyang perfusiondeficitsandfunctionalconnectivityalterationsinmemoryrelatedregionsofpatientswithposttraumaticstressdisorder AT libaojuan perfusiondeficitsandfunctionalconnectivityalterationsinmemoryrelatedregionsofpatientswithposttraumaticstressdisorder AT fengna perfusiondeficitsandfunctionalconnectivityalterationsinmemoryrelatedregionsofpatientswithposttraumaticstressdisorder AT puhuangsheng perfusiondeficitsandfunctionalconnectivityalterationsinmemoryrelatedregionsofpatientswithposttraumaticstressdisorder AT zhangxi perfusiondeficitsandfunctionalconnectivityalterationsinmemoryrelatedregionsofpatientswithposttraumaticstressdisorder AT luhongbing perfusiondeficitsandfunctionalconnectivityalterationsinmemoryrelatedregionsofpatientswithposttraumaticstressdisorder AT yinhong perfusiondeficitsandfunctionalconnectivityalterationsinmemoryrelatedregionsofpatientswithposttraumaticstressdisorder |