In Vitro and In Vivo Modulation of Alternative Splicing by the Biguanide Metformin

Major physiological changes are governed by alternative splicing of RNA, and its misregulation may lead to specific diseases. With the use of a genome-wide approach, we show here that this splicing step can be modified by medication and demonstrate the effects of the biguanide metformin, on alternat...

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Detalles Bibliográficos
Autores principales: Laustriat, Delphine, Gide, Jacqueline, Barrault, Laetitia, Chautard, Emilie, Benoit, Clara, Auboeuf, Didier, Boland, Anne, Battail, Christophe, Artiguenave, François, Deleuze, Jean-François, Bénit, Paule, Rustin, Pierre, Franc, Sylvia, Charpentier, Guillaume, Furling, Denis, Bassez, Guillaume, Nissan, Xavier, Martinat, Cécile, Peschanski, Marc, Baghdoyan, Sandrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877444/
https://www.ncbi.nlm.nih.gov/pubmed/26528939
http://dx.doi.org/10.1038/mtna.2015.35

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