Epstein-Barr Virus-Induced Gene 3 (EBI3) Blocking Leads to Induce Antitumor Cytotoxic T Lymphocyte Response and Suppress Tumor Growth in Colorectal Cancer by Bidirectional Reciprocal-Regulation STAT3 Signaling Pathway

Epstein-Barr virus-induced gene 3 (EBI3) is a member of the interleukin-12 (IL-12) family structural subunit and can form a heterodimer with IL-27p28 and IL-12p35 subunit to build IL-27 and IL-35, respectively. However, IL-27 stimulates whereas IL-35 inhibits antitumor T cell responses. To date, lit...

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Detalles Bibliográficos
Autores principales: Liang, Yanfang, Chen, Qianqian, Du, Wenjing, Chen, Can, Li, Feifei, Yang, Jingying, Peng, Jianyu, Kang, Dongping, Lin, Bihua, Chai, Xingxing, Zhou, Keyuan, Zeng, Jincheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877478/
https://www.ncbi.nlm.nih.gov/pubmed/27247488
http://dx.doi.org/10.1155/2016/3214105

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